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    LRP5 LDL receptor related protein 5 [ Bos taurus (domestic cattle) ]

    Gene ID: 534450, updated on 29-Jan-2025

    Summary

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    Official Symbol
    LRP5provided by VGNC
    Official Full Name
    LDL receptor related protein 5provided by VGNC
    Primary source
    VGNC:VGNC:97281
    See related
    Ensembl:ENSBTAG00000005903
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LRP5L
    Orthologs
    human mouse all
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    Genomic context

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    See LRP5 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (45803314..45927823)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene chromosome 29 C11orf24 homolog Neighboring gene uncharacterized LOC112444893 Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene galanin and GMAP prepropeptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bovine anterior pituitary progenitor cell line expresses interleukin (IL)-18 and IL-18 receptor. Nagai Y, et al. J Neuroendocrinol, 2008 Nov. PMID 18761716
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Wnt receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bone marrow development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bone remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in osteoblast development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retinal blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 5-like protein; low-density lipoprotein receptor-related protein 5
    Names
    LDL receptor related protein 5 like
    low density lipoprotein receptor-related protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45803314..45927823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987583.2 → XP_024843351.1  low-density lipoprotein receptor-related protein 5 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TJL5, F1N1K8
      Related
      ENSBTAP00070042242.1, ENSBTAT00070069318.1
      Conserved Domains (7) summary
      smart00135
      Location:408 → 450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1346 → 1380
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720 → 756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1258 → 1295
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163 → 203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:685 → 878
      NHL; NHL repeat unit of beta-propeller proteins
      pfam14670
      Location:299 → 336
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_024987586.2 → XP_024843354.1  low-density lipoprotein receptor-related protein 5 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TJL5
      Conserved Domains (7) summary
      smart00135
      Location:408 → 450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1336 → 1370
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720 → 756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1258 → 1295
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163 → 203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:685 → 878
      NHL; NHL repeat unit of beta-propeller proteins
      pfam14670
      Location:299 → 336
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_024987588.2 → XP_024843356.1  low-density lipoprotein receptor-related protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1N396, A0AAA9TJL5
      Related
      ENSBTAP00070042264.1, ENSBTAT00070069370.1
      Conserved Domains (6) summary
      smart00135
      Location:408 → 450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1257 → 1291
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720 → 756
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:163 → 203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:685 → 878
      NHL; NHL repeat unit of beta-propeller proteins
      pfam14670
      Location:299 → 336
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_024987585.2 → XP_024843353.1  low-density lipoprotein receptor-related protein 5 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TJL5
      Conserved Domains (7) summary
      smart00135
      Location:408 → 450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1345 → 1379
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720 → 756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1257 → 1294
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163 → 203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:685 → 878
      NHL; NHL repeat unit of beta-propeller proteins
      pfam14670
      Location:299 → 336
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. XM_024987587.2 → XP_024843355.1  low-density lipoprotein receptor-related protein 5 isoform X4

      UniProtKB/TrEMBL
      A0AAA9TJL5
      Conserved Domains (7) summary
      smart00135
      Location:408 → 450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1335 → 1369
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720 → 756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1257 → 1294
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163 → 203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:685 → 878
      NHL; NHL repeat unit of beta-propeller proteins
      pfam14670
      Location:299 → 336
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version

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