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    MEF2A myocyte enhancer factor 2A [ Bos taurus (domestic cattle) ]

    Gene ID: 407231, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MEF2Aprovided by VGNC
    Official Full Name
    myocyte enhancer factor 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:31372
    See related
    BGD:BT12322; Ensembl:ENSBTAG00000010649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MEF2A in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (6860314..7040879, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17 Neighboring gene uncharacterized LOC132343325 Neighboring gene LysM domain containing 4 Neighboring gene uncharacterized LOC132343326 Neighboring gene leucine rich repeat containing 28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells. Sun J, et al. Genes (Basel), 2023 Jul 22. PMID 37510401, Free PMC Article
    2. Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast. Wang YN, et al. PLoS One, 2018. PMID 29698438, Free PMC Article
    3. Promoter variant-dependent mRNA expression of the MEF2A in longissimus dorsi muscle in cattle. Juszczuk-Kubiak E, et al. DNA Cell Biol, 2012 Jun. PMID 22320864, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells.
      Title: Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells.
    2. MEF2A is a positive regulator in skeletal muscle myoblast proliferation
      Title: Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast.
    3. polymorphisms in the bovine MEF2A gene and their effect on the MEF2A mRNA expression level in the longissimus dorsi muscle
      Title: Promoter variant-dependent mRNA expression of the MEF2A in longissimus dorsi muscle in cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myocyte-specific enhancer factor 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083638.2 → NP_001077107.1  myocyte-specific enhancer factor 2A

      See identical proteins and their annotated locations for NP_001077107.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133487
      UniProtKB/Swiss-Prot
      A2VDZ3
      Related
      ENSBTAP00000014074.4, ENSBTAT00000014074.5
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6860314..7040879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221713.5 → XP_005221770.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_005221770.1

      UniProtKB/TrEMBL
      D2KFG0
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    2. XM_005221712.5 → XP_005221769.1  myocyte-specific enhancer factor 2A isoform X1

      See identical proteins and their annotated locations for XP_005221769.1

      UniProtKB/TrEMBL
      D2KFG0
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    3. XM_005221716.5 → XP_005221773.1  myocyte-specific enhancer factor 2A isoform X3

      See identical proteins and their annotated locations for XP_005221773.1

      UniProtKB/TrEMBL
      A0A3Q1MDU1
      Related
      ENSBTAP00000068625.1, ENSBTAT00000076961.2
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    4. XM_005221715.5 → XP_005221772.1  myocyte-specific enhancer factor 2A isoform X2

      See identical proteins and their annotated locations for XP_005221772.1

      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    5. XM_059878953.1 → XP_059734936.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      D2KFG0

    6. XM_059878955.1 → XP_059734938.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      D2KFG0

    7. XM_059878952.1 → XP_059734935.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      D2KFG0

    8. XM_059878954.1 → XP_059734937.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      D2KFG0

    9. XM_059878956.1 → XP_059734939.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/TrEMBL
      D2KFG0

    10. XM_059878958.1 → XP_059734941.1  myocyte-specific enhancer factor 2A isoform X6

    11. XM_010816885.4 → XP_010815187.1  myocyte-specific enhancer factor 2A isoform X5

      See identical proteins and their annotated locations for XP_010815187.1

      Conserved Domains (1) summary
      pfam12347
      Location:14 → 66
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    12. XM_059878957.1 → XP_059734940.1  myocyte-specific enhancer factor 2A isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VDZ3.1 GenPept UniProtKB/Swiss-Prot:A2VDZ3

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