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    psq pipsqueak [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psqprovided by FlyBase
    Official Full Name
    pipsqueakprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263102
    Locus tag
    Dmel_CG2368
    See related
    AllianceGenome:FB:FBgn0263102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BTB-V; BtbV; CG2368; Dmel\CG2368; eyeful; Lola; pip; Pipsqueak; Piq; psk; Psq; PSQ; psq-1; rum; zep
    Summary
    Enables POZ domain binding activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in embryonic pattern specification; heterochromatin formation; and imaginal disc-derived wing morphogenesis. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including amnioserosa; gnathal segment; imaginal disc; outer photoreceptor cell; and photoreceptor precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See psq in Genome Data Viewer
    Location:
    47A13-47B1; 2-62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10557888..10617280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6445393..6504785)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene longitudinals lacking Neighboring gene antisense RNA:CR45135 Neighboring gene long non-coding RNA:acal Neighboring gene uncharacterized protein Neighboring gene G protein-coupled receptor kinase interacting ArfGAP

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small RNA analysis provides new insights into cytoplasmic incompatibility in Drosophila melanogaster induced by Wolbachia. Zheng Y, et al. J Insect Physiol, 2019 Oct. PMID 31491378
    2. Aberrant splicing and transcription termination caused by P element insertion into the intron of a Drosophila gene. Horowitz H, et al. Genetics, 1995 Jan. PMID 7705633, Free PMC Article
    3. High-resolution mapping of transcription factor binding sites on native chromatin. Kasinathan S, et al. Nat Methods, 2014 Feb. PMID 24336359, Free PMC Article
    4. Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12271134, Free PMC Article
    5. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. Horowitz H, et al. Development, 1996 Jun. PMID 8674425

    See all (178) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
      Title: Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
    2. whereas the bab locus controls the sorting of TFCs into TFs, psq plays a major function in global control of TFC number, without affecting sorting of TFCs into TFs.
      Title: Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors.
    3. characterized a new psq loss-of-function allele, psq(rum), which specifically affects signaling by the Torso (Tor) receptor tyrosine kinase (RTK)
      Title: Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila.
    4. Pipsqueak and GAGA factor are co-localized on polytene interphase chromosomes of Drosophila
      Title: Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci.
    5. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins, which includes proteins from fungi, sea urchins, nematodes, insects, and vertebrates
      Title: The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins.
    6. Pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex.
      Title: pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex.
    7. the eyeful P-element insertion, which induces overexpression of lola and psq, combined with Delta overexpression induces metastatic tumors
      Title: Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables POZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo HMP PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pipsqueak
    Names
    BTB-protein-V
    CG2368-PA
    CG2368-PB
    CG2368-PC
    CG2368-PD
    CG2368-PE
    CG2368-PF
    CG2368-PG
    CG2368-PH
    CG2368-PJ
    CG2368-PK
    CG2368-PM
    CG2368-PN
    CG2368-PO
    CG2368-PP
    CG2368-PQ
    eyeful
    peepsqueak
    pipsqeak
    psq-PA
    psq-PB
    psq-PC
    psq-PD
    psq-PE
    psq-PF
    psq-PG
    psq-PH
    psq-PJ
    psq-PK
    psq-PM
    psq-PN
    psq-PO
    psq-PP
    psq-PQ
    rumpf
    zeppelin
    zepplin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10557888..10617280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382049.1 → NP_001369078.1  pipsqueak, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7H0, Q24184, Q24187, Q9V5N1, Q9V5N2
      Conserved Domains (2) summary
      pfam05225
      Location:873 → 916
      HTH_psq; helix-turn-helix, Psq domain
      cd18315
      Location:34 → 118
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    2. NM_001014520.3 → NP_001014520.2  pipsqueak, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014520.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8A6, Q24184, Q24187, Q9V5N1, Q9V5N2
      Conserved Domains (3) summary
      smart00225
      Location:36 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:25 → 125
      BTB; BTB/POZ domain
      pfam05225
      Location:873 → 916
      HTH_psq; helix-turn-helix, Psq domain

    3. NM_001316414.1 → NP_001303343.1  pipsqueak, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUM1, Q24184, Q24187, Q9V5N1, Q9V5N2
      Conserved Domains (3) summary
      smart00225
      Location:36 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:25 → 125
      BTB; BTB/POZ domain
      pfam05225
      Location:873 → 916
      HTH_psq; helix-turn-helix, Psq domain

    4. NM_078962.4 → NP_523686.2  pipsqueak, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523686.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24184, Q24187, Q7K0T7, Q9V5N1, Q9V5N2
      Related
      FBpp0087368
      Conserved Domains (3) summary
      smart00225
      Location:36 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:25 → 125
      BTB; BTB/POZ domain
      pfam05225
      Location:889 → 932
      HTH_psq; helix-turn-helix, Psq domain

    5. NM_165790.3 → NP_724955.1  pipsqueak, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8A4, Q24184, Q24187, Q9V5N1, Q9V5N2
      Related
      FBpp0087369
      Conserved Domains (3) summary
      smart00225
      Location:36 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:25 → 125
      BTB; BTB/POZ domain
      pfam05225
      Location:871 → 914
      HTH_psq; helix-turn-helix, Psq domain

    6. NM_206086.3 → NP_995808.1  pipsqueak, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24184, Q24187, Q7K0T7, Q9V5N1, Q9V5N2
      Conserved Domains (3) summary
      smart00225
      Location:36 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:25 → 125
      BTB; BTB/POZ domain
      pfam05225
      Location:889 → 932
      HTH_psq; helix-turn-helix, Psq domain

    7. NM_165792.3 → NP_724959.1  pipsqueak, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C8, Q7JP00
      Related
      FBpp0087370
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    8. NM_176141.3 → NP_788321.1  pipsqueak, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C8, Q7JP00
      Related
      FBpp0087372
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    9. NM_176142.3 → NP_788322.1  pipsqueak, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C8, Q7JP00
      Related
      FBpp0087373
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    10. NM_001014518.3 → NP_001014518.1  pipsqueak, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZC9, Q7JP00
      Conserved Domains (1) summary
      pfam05225
      Location:464 → 507
      HTH_psq; helix-turn-helix, Psq domain

    11. NM_001014519.3 → NP_001014519.1  pipsqueak, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZC9, Q7JP00
      Conserved Domains (1) summary
      pfam05225
      Location:464 → 507
      HTH_psq; helix-turn-helix, Psq domain

    12. NM_001382050.1 → NP_001369079.1  pipsqueak, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3QAD4, Q7JP00
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    13. NM_001382051.1 → NP_001369080.1  pipsqueak, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7A2
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    14. NM_165791.3 → NP_724958.1  pipsqueak, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C8, Q7JP00
      Related
      FBpp0087371
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain

    15. NM_176143.3 → NP_788323.1  pipsqueak, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C8, Q7JP00
      Related
      FBpp0087374
      Conserved Domains (1) summary
      pfam05225
      Location:470 → 513
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUM1 A0A126GUM1
    A0A6M3Q7A2 A0A6M3Q7A2
    A0A6M3Q7H0 A0A6M3Q7H0
    A0A6M3QAD4 A0A6M3QAD4
    A1Z8A4 A1Z8A4
    A1Z8A6 A1Z8A6
    A4UZC9 A4UZC9
    Q0E9C8 Q0E9C8
    Q24455 Q24455
    Q24457 Q24457
    Q7JN04 Q7JN04
    Q7JP00 Q7JP00
    Q7JPL8 Q7JPL8
    Q7K0T7 Q7K0T7
    Q9V5N1 Q9V5N1

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