ARA1 D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: ARA1
Official Full Name: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1
Primary source: SGD:S000000353
Locus tag: YBR149W
See related: AllianceGenome:SGD:S000000353; FungiDB:YBR149W; VEuPathDB:YBR149W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables D-arabinose 1-dehydrogenase [NAD(P)+] activity and diacetyl reductase ((S)-acetoin forming) (NAD+) activity. Involved in acetoin metabolic process and carbohydrate metabolic process. Is active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ARA1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (539987..541021)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A structural study of Ara1 revealed that induced fit upon NADPH binding yielded an intact active-site pocket that recognizes the substrate.
Title: Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition.
Characterizeion of Ara1 as an oxidoreductase that can reduce racemic acetoin to meso-2,3-butanediol and (2S,3S)-2,3-butanediol in the presence of NADPH.
Title: Role of Saccharomyces cerevisiae oxidoreductases Bdh1p and Ara1p in the metabolism of acetoin and 2,3-butanediol.
It demonstrates that Ara2p, not Ara1p, mainly contributes to the production of Erythroascorbic acid from d-arabinose in S. cerevisiae.
Title: NAD+-specific D-arabinose dehydrogenase and its contribution to erythroascorbic acid production in Saccharomyces cerevisiae.
Ara1p catalyzed the reduction of the reactive alpha,beta-dicarbonyl compounds methylglyoxal, diacetyl, and pentanedione in a NADPH dependant manner.
Title: Alpha,beta-dicarbonyl reduction by Saccharomyces D-arabinose dehydrogenase.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-arabinose 1-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables D-arabinose 1-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables D-arabinose 1-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables D-arabinose 1-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacetyl reductase ((S)-acetoin forming) (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetoin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1

NP_009707.3

EC 1.1.1.117

NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

539987..541021

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178497.3 → NP_009707.3 TPA: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009707.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQE4, P38115

UniProtKB/TrEMBL

A6ZL91, B3LN10, C7GY29, D3UEP3, N1PAT8

Conserved Domains (1) summary

cd19119
Location:22 → 321

AKR_AKR3C1; Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins