AMD1 AMP deaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AMD1
Official Full Name: AMP deaminase
Primary source: SGD:S000004498
Locus tag: YML035C
See related: AllianceGenome:SGD:S000004498; FungiDB:YML035C; VEuPathDB:YML035C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AMD3
Summary: Enables AMP deaminase activity. Involved in guanine salvage and purine nucleotide metabolic process. Located in cytoplasm. Used to study pontocerebellar hypoplasia. Human ortholog(s) of this gene implicated in congestive heart failure; coronary artery disease; hereditary spastic paraplegia 63; and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD1 (adenosine monophosphate deaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AMD1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (206428..208860, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
Title: Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
Results show that Deletion of AMD1 affects growth in the presence of adenine and impairs purine nucleotide balance.
Title: Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables AMP deaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in guanine salvage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in guanine salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in purine nucleotide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AMP deaminase

NP_013677.1

EC 3.5.4.6

AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

206428..208860 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182392.1 → NP_013677.1 TPA: AMP deaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013677.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZE0, P15274

UniProtKB/TrEMBL

A6ZM28, B3LLL8, C7GT64, G2WK18, N1NZ21

Conserved Domains (1) summary

cd01319
Location:299 → 794

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.