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    sym-2 RNA-binding protein sym-2;RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174461, updated on 9-Dec-2024

    Summary

    Official Symbol
    sym-2
    Official Full Name
    RNA-binding protein sym-2;RRM domain-containing protein
    Primary source
    WormBase:WBGene00006367
    Locus tag
    CELE_ZK1067.6
    See related
    AllianceGenome:WB:WBGene00006367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sym-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (9178514..9188480, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1 Neighboring gene Exocyst complex component 2 Neighboring gene RNA/RNP complex-1-interacting phosphatase homolog Neighboring gene Potassium channel domain-containing protein Neighboring gene Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase Neighboring gene ncRNA Neighboring gene Transmembrane protein 151 homolog Neighboring gene ncRNA Neighboring gene tRNA-Tyr

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding PubMed 
    enables mRNA binding  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in embryonic body morphogenesis PubMed 
    involved_in mRNA processing  
    involved_in multicellular organismal movement PubMed 
    involved_in regulation of RNA splicing  
    involved_in regulation of RNA splicing PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm  
    located_in nucleus  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    RNA-binding protein sym-2;RRM domain-containing protein
    NP_001300608.1
    • Partially confirmed by transcript evidence
    NP_495960.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9178514..9188480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063559.10 → NP_495960.2  RNA-binding protein sym-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495960.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22708, Q23391, Q86GJ8
      Conserved Domains (4) summary
      COG0724
      Location:282 → 446
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12507
      Location:182 → 256
      RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
      cd12508
      Location:281 → 355
      RRM2_ESRPs_Fusilli; RNA recognition motif 2 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
      cd12743
      Location:388 → 472
      RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    2. NM_001313679.3 → NP_001300608.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARR9
      Conserved Domains (2) summary
      cd12508
      Location:9 → 83
      RRM2_ESRPs_Fusilli; RNA recognition motif 2 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
      cl17169
      Location:116 → 200
      RRM_SF; RNA recognition motif (RRM) superfamily
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