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    atp-3 ATP synthase subunit O, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp-3
    Official Full Name
    ATP synthase subunit O, mitochondrial
    Primary source
    WormBase:WBGene00000230
    Locus tag
    CELE_F27C1.7
    See related
    AllianceGenome:WB:WBGene00000230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in determination of adult lifespan and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5428545..5429819, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small-subunit processome Neighboring gene uncharacterized protein Neighboring gene Dauer Up-Regulated Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Copper transport protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bridging the phenotypic gap: real-time assessment of mitochondrial function and metabolism of the nematode Caenorhabditis elegans. Lagido C, et al. BMC Physiol, 2008 Apr 2. PMID 18384668, Free PMC Article
    2. Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans. Vukoti K, et al. J Proteome Res, 2015 Mar 6. PMID 25686393, Free PMC Article
    3. Expression of a FRET-based ATP Biosensor in the C. elegans Intestine. Soto J, et al. MicroPubl Biol, 2020 Jul 30. PMID 32760881, Free PMC Article
    4. Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase. Qi B, et al. Cell, 2018 Oct 4. PMID 30146159
    5. ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans. Kawasaki I, et al. Mech Dev, 2007 Mar. PMID 17223323

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit O, mitochondrial
    NP_001021421.1
    • Confirmed by transcript evidence
    NP_001370527.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5428545..5429819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383096.2 → NP_001370527.1  ATP synthase subunit O, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91283
      Conserved Domains (1) summary
      pfam00213
      Location:30 → 203
      OSCP; ATP synthase delta (OSCP) subunit

    2. NM_001026250.7 → NP_001021421.1  ATP synthase subunit O, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNG1
      Conserved Domains (1) summary
      pfam00213
      Location:51 → 224
      OSCP; ATP synthase delta (OSCP) subunit
    Nucleotide Protein
    Heading Accession and Version

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