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    itr-1 Inositol 1,4,5-trisphosphate receptor itr-1 [ Caenorhabditis elegans ]

    Gene ID: 177546, updated on 9-Dec-2024

    Summary

    Official Symbol
    itr-1
    Official Full Name
    Inositol 1,4,5-trisphosphate receptor itr-1
    Primary source
    WormBase:WBGene00002173
    Locus tag
    CELE_F33D4.2
    See related
    AllianceGenome:WB:WBGene00002173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode pharyngeal pumping; and sperm ejaculation. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See itr-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    38
    Sequence:
    Chromosome: IV; NC_003282.8 (7675174..7696930)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPSAVPLIRF-amide Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity  
    enables calcium ion binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity  
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity PubMed 
    enables monoatomic ion channel activity  
    enables myosin binding PubMed 
    enables phosphatidylinositol binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in defecation PubMed 
    involved_in defecation PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in embryonic morphogenesis PubMed 
    involved_in male mating behavior PubMed 
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transport  
    involved_in multicellular organismal reproductive process PubMed 
    involved_in muscle contraction PubMed 
    involved_in oocyte maturation PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of nematode pharyngeal pumping PubMed 
    involved_in programmed cell death PubMed 
    involved_in regulation of cell migration PubMed 
    involved_in regulation of filopodium assembly PubMed 
    involved_in regulation of nematode pharyngeal pumping PubMed 
    involved_in regulation of nematode pharyngeal pumping PubMed 
    involved_in release of sequestered calcium ion into cytosol  
    involved_in rhythmic behavior PubMed 
    involved_in sperm ejaculation PubMed 
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in endomembrane system  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in intracellular membrane-bounded organelle  
    located_in membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    is_active_in sarcoplasmic reticulum  
    is_active_in secretory granule membrane  

    General protein information

    Preferred Names
    Inositol 1,4,5-trisphosphate receptor itr-1
    NP_001023170.1
    • Confirmed by transcript evidence
    NP_001023171.1
    • Confirmed by transcript evidence
    NP_001023172.1
    • Confirmed by transcript evidence
    NP_001023173.1
    • Confirmed by transcript evidence
    NP_001255305.1
    • Confirmed by transcript evidence
    NP_001367466.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7675174..7696930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027999.4 → NP_001023170.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3NQ87, G5EBF6, Q8MXI9, Q9U3B3, Q9Y0A0, Q9Y0A1
      Conserved Domains (8) summary
      TIGR04370
      Location:2452 → 2640
      glyco_rpt_poly; oligosaccharide repeat unit polymerase
      pfam00520
      Location:2570 → 2764
      Ion_trans; Ion transport protein
      pfam01365
      Location:593 → 787
      RYDR_ITPR; RIH domain
      pfam02815
      Location:320 → 548
      MIR; MIR domain
      pfam06432
      Location:2447 → 2539
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
      pfam08454
      Location:2073 → 2176
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:78 → 312
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cl01736
      Location:2507 → 2636
      PelG; Putative exopolysaccharide Exporter (EPS-E)
    2. NM_001028000.5 → NP_001023171.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y0A1
      Conserved Domains (8) summary
      TIGR04370
      Location:2396 → 2584
      glyco_rpt_poly; oligosaccharide repeat unit polymerase
      pfam00520
      Location:2514 → 2708
      Ion_trans; Ion transport protein
      pfam01365
      Location:537 → 731
      RYDR_ITPR; RIH domain
      pfam02815
      Location:264 → 492
      MIR; MIR domain
      pfam06432
      Location:2391 → 2483
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
      pfam08454
      Location:2017 → 2120
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:22 → 256
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cl01736
      Location:2451 → 2580
      PelG; Putative exopolysaccharide Exporter (EPS-E)
    3. NM_001028001.5 → NP_001023172.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y0A1
      Conserved Domains (8) summary
      TIGR04370
      Location:2417 → 2605
      glyco_rpt_poly; oligosaccharide repeat unit polymerase
      pfam00520
      Location:2535 → 2729
      Ion_trans; Ion transport protein
      pfam01365
      Location:556 → 750
      RYDR_ITPR; RIH domain
      pfam02815
      Location:274 → 511
      MIR; MIR domain
      pfam06432
      Location:2412 → 2504
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
      pfam08454
      Location:2038 → 2141
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:32 → 266
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cl01736
      Location:2472 → 2601
      PelG; Putative exopolysaccharide Exporter (EPS-E)
    4. NM_001028002.4 → NP_001023173.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y0A1
      Conserved Domains (8) summary
      TIGR04370
      Location:2406 → 2594
      glyco_rpt_poly; oligosaccharide repeat unit polymerase
      pfam00520
      Location:2524 → 2718
      Ion_trans; Ion transport protein
      pfam01365
      Location:547 → 741
      RYDR_ITPR; RIH domain
      pfam02815
      Location:274 → 502
      MIR; MIR domain
      pfam06432
      Location:2401 → 2493
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
      pfam08454
      Location:2027 → 2130
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:32 → 266
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cl01736
      Location:2461 → 2590
      PelG; Putative exopolysaccharide Exporter (EPS-E)
    5. NM_001268376.4 → NP_001255305.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255305.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y0A1
      Conserved Domains (8) summary
      TIGR04370
      Location:2427 → 2615
      glyco_rpt_poly; oligosaccharide repeat unit polymerase
      pfam00520
      Location:2545 → 2739
      Ion_trans; Ion transport protein
      pfam01365
      Location:547 → 741
      RYDR_ITPR; RIH domain
      pfam02815
      Location:274 → 502
      MIR; MIR domain
      pfam06432
      Location:2422 → 2514
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
      pfam08454
      Location:2048 → 2151
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:32 → 266
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cl01736
      Location:2482 → 2611
      PelG; Putative exopolysaccharide Exporter (EPS-E)
    6. NM_001380339.2 → NP_001367466.1  Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam01365
      Location:545 → 746
      RYDR_ITPR; RIH domain
      pfam02815
      Location:274 → 502
      MIR; MIR domain
      pfam08709
      Location:32 → 271
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
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