U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ncl-1 B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 176084, updated on 9-Dec-2024

    Summary

    Official Symbol
    ncl-1
    Official Full Name
    B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00003559
    Locus tag
    CELE_ZK112.2
    See related
    AllianceGenome:WB:WBGene00003559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables translation repressor activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of ribosome biogenesis; and nucleologenesis. Located in cytoplasm. Is expressed in several structures, including anal depressor muscle; head; intestine; pharynx; and tail. Orthologous to human TRIM3 (tripartite motif containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ncl-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (7719729..7738105)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene AMP-binding domain-containing protein Neighboring gene Cadherin-3 Neighboring gene ncRNA Neighboring gene Putative serine protease pcp-1

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding  
    enables transferase activity  
    enables translation repressor activity  
    enables translation repressor activity PubMed 
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  

    General protein information

    Preferred Names
    B box-type domain-containing protein;B-box type zinc finger protein ncl-1;RING-type E3 ubiquitin transferase
    NP_001299852.1
    • Confirmed by transcript evidence
    NP_001299853.1
    • Confirmed by transcript evidence
    NP_001299924.1
    • Confirmed by transcript evidence
    NP_001299926.1
    • Confirmed by transcript evidence
    NP_001299927.1
    • Confirmed by transcript evidence
    NP_001299928.1
    • Confirmed by transcript evidence
    NP_001368538.1
    • Confirmed by transcript evidence
    NP_001379611.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7719729..7738105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001312923.3 → NP_001299852.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX41
      Conserved Domains (4) summary
      smart00502
      Location:396 → 522
      BBC; B-Box C-terminal domain
      smart00336
      Location:346 → 389
      BBOX; B-Box-type zinc finger
      cd00162
      Location:87 → 131
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:694 → 964
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    2. NM_001312924.2 → NP_001299853.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARS2
      Conserved Domains (4) summary
      smart00502
      Location:399 → 525
      BBC; B-Box C-terminal domain
      smart00336
      Location:349 → 392
      BBOX; B-Box-type zinc finger
      cd00162
      Location:87 → 131
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:697 → 967
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    3. NM_001312995.3 → NP_001299924.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUA6
      Conserved Domains (4) summary
      smart00502
      Location:387 → 513
      BBC; B-Box C-terminal domain
      smart00336
      Location:337 → 380
      BBOX; B-Box-type zinc finger
      cd00162
      Location:75 → 119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:685 → 955
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    4. NM_001379801.1 → NP_001368538.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARF3
      Conserved Domains (6) summary
      smart00502
      Location:384 → 510
      BBC; B-Box C-terminal domain
      cd14959
      Location:682 → 952
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      TIGR00599
      Location:75 → 181
      rad18; DNA repair protein rad18
      cd19798
      Location:334 → 377
      Bbox2_BRAT-like; B-box-type 2 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cd19813
      Location:247 → 290
      Bbox1_BRAT-like; B-box-type 1 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cl17238
      Location:75 → 119
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    5. NM_001392143.1 → NP_001379611.1  B-box type zinc finger protein ncl-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34611
      Conserved Domains (4) summary
      smart00502
      Location:268 → 394
      BBC; B-Box C-terminal domain
      cd14959
      Location:566 → 836
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      cd19798
      Location:218 → 261
      Bbox2_BRAT-like; B-box-type 2 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
      cd19813
      Location:131 → 174
      Bbox1_BRAT-like; B-box-type 1 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
    6. NM_001312997.3 → NP_001299926.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUY6
      Conserved Domains (4) summary
      smart00502
      Location:333 → 459
      BBC; B-Box C-terminal domain
      smart00336
      Location:283 → 326
      BBOX; B-Box-type zinc finger
      cd00162
      Location:21 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:631 → 901
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    7. NM_001312998.3 → NP_001299927.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXB1
      Conserved Domains (4) summary
      smart00502
      Location:330 → 456
      BBC; B-Box C-terminal domain
      smart00336
      Location:280 → 323
      BBOX; B-Box-type zinc finger
      cd00162
      Location:21 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14959
      Location:628 → 898
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    8. NM_001312999.3 → NP_001299928.1  B box-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS01
      Conserved Domains (3) summary
      smart00502
      Location:271 → 397
      BBC; B-Box C-terminal domain
      smart00336
      Location:221 → 264
      BBOX; B-Box-type zinc finger
      cd14959
      Location:569 → 839
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    External link. Please review our privacy policy.