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    gsto-3 GST N-terminal domain-containing protein;Glutathione-dependent dehydroascorbate reductase [ Caenorhabditis elegans ]

    Gene ID: 175196, updated on 4-Jan-2025

    Summary

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    Official Symbol
    gsto-3
    Official Full Name
    GST N-terminal domain-containing protein;Glutathione-dependent dehydroascorbate reductase
    Primary source
    WormBase:WBGene00019636
    Locus tag
    CELE_K10F12.4
    See related
    AllianceGenome:WB:WBGene00019636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See gsto-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (378137..381298, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene Phosphoinositide phospholipase C Neighboring gene Ovule protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GST N-terminal domain-containing protein;Glutathione-dependent dehydroascorbate reductase
    NP_001380016.1
    • Confirmed by transcript evidence
    NP_741069.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      378137..381298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171061.1 → NP_741069.1  Glutathione-dependent dehydroascorbate reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17234
      Conserved Domains (2) summary
      cd03184
      Location:182 → 308
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:81 → 168
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_001393255.1 → NP_001380016.1  GST N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA74
      Conserved Domains (1) summary
      cl00388
      Location:81 → 123
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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