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    chc-1 putative clathrin heavy chain 1 [ Caenorhabditis elegans ]

    Gene ID: 176434, updated on 9-Dec-2024

    Summary

    Official Symbol
    chc-1
    Official Full Name
    putative clathrin heavy chain 1
    Primary source
    WormBase:WBGene00011867
    Locus tag
    CELE_T20G5.1
    See related
    AllianceGenome:WB:WBGene00011867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin light chain binding activity. Involved in several processes, including apical protein localization; determination of adult lifespan; and positive regulation of clathrin-dependent endocytosis. Located in several cellular components, including apical plasma membrane; clathrin-coated endocytic vesicle; and mitotic spindle. Is expressed in coelomocyte; germ line; hypodermal cell; intestine; and pharyngeal cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See chc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (10203821..10209704)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene Partner of Y14 and mago Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 1 Neighboring gene Bestrophin homolog;Bestrophin homolog 18 Neighboring gene putative citrate synthase, mitochondrial

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin light chain binding  
    enables clathrin light chain binding  
    enables protein binding PubMed 
    enables structural molecule activity  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    is_active_in cell cortex  
    located_in cell cortex PubMed 
    part_of clathrin coat of coated pit  
    part_of clathrin coat of trans-Golgi network vesicle  
    part_of clathrin complex  
    part_of clathrin complex  
    is_active_in clathrin-coated endocytic vesicle  
    located_in clathrin-coated endocytic vesicle PubMed 
    located_in clathrin-coated pit  
    located_in cytoplasm PubMed 
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytoplasmic vesicle PubMed 
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in endocytic vesicle PubMed 
    located_in mitotic spindle PubMed 
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    putative clathrin heavy chain 1
    NP_499260.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10203821..10209704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066859.5 → NP_499260.1  putative clathrin heavy chain 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34574
      Conserved Domains (5) summary
      smart00299
      Location:1276 → 1418
      CLH; Clathrin heavy chain repeat homology
      pfam00637
      Location:985 → 1121
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:196 → 232
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:329 → 351
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:362 → 419
      Clathrin_H_link; Clathrin-H-link
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