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    gpaa-1 Chitin synthase;GPI transamidase component GAA1;GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 172256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpaa-1
    Official Full Name
    Chitin synthase;GPI transamidase component GAA1;GlycosylPhosphatidylinositol Anchor Attachment 1 homolog
    Primary source
    WormBase:WBGene00018006
    Locus tag
    CELE_F33D11.9
    See related
    AllianceGenome:WB:WBGene00018006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in attachment of GPI anchor to protein. Predicted to be located in membrane. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpaa-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (5857547..5862557, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene Neuropeptide Neighboring gene ncRNA Neighboring gene Palmitoyltransferase Neighboring gene Uncharacterized protein Neighboring gene RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. Barberan-Soler S, et al. PLoS Genet, 2008 Feb 29. PMID 18454200, Free PMC Article
    2. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chitin synthase;GPI transamidase component GAA1;GlycosylPhosphatidylinositol Anchor Attachment 1 homolog
    NP_001309523.1
    • Partially confirmed by transcript evidence
    NP_001309526.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa
    NP_001309527.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa
    NP_001309528.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa
    NP_001309529.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa
    NP_001309530.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa
    NP_001367611.1
    • Partially confirmed by transcript evidence
    NP_001368589.1
    • Confirmed by transcript evidence
    NP_001368590.1
    • Confirmed by transcript evidence
    NP_001379761.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class gpaa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5857547..5862557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322677.3 → NP_001309523.1  Chitin synthase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBA2
      Conserved Domains (1) summary
      cl14876
      Location:136 → 574
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. NM_001392367.1 → NP_001379761.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44780
      Conserved Domains (1) summary
      cl14876
      Location:1 → 235
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. NM_001380401.1 → NP_001367611.1  Chitin synthase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95X60
      Conserved Domains (1) summary
      pfam04114
      Location:136 → 629
      Gaa1; Gaa1-like, GPI transamidase component

    4. NM_001380403.1 → NP_001368589.1  Chitin synthase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MC59
      Conserved Domains (1) summary
      pfam04114
      Location:120 → 613
      Gaa1; Gaa1-like, GPI transamidase component

    5. NM_001380402.1 → NP_001368590.1  GPI transamidase component GAA1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCX4
      Conserved Domains (1) summary
      cl14876
      Location:120 → 560
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    6. NM_001322680.3 → NP_001309526.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBB0
      Conserved Domains (1) summary
      cl14876
      Location:1 → 180
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    7. NM_001322681.3 → NP_001309528.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCK4
      Conserved Domains (1) summary
      cl14876
      Location:2 → 118
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    8. NM_001322682.3 → NP_001309527.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBI5
      Conserved Domains (1) summary
      cl14876
      Location:2 → 171
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    9. NM_001322683.3 → NP_001309529.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCQ6
      Conserved Domains (1) summary
      cl14876
      Location:1 → 123
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    10. NM_001322684.3 → NP_001309530.1  GlycosylPhosphatidylinositol Anchor Attachment 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBD4
      Conserved Domains (1) summary
      cl14876
      Location:9 → 50
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein
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