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    dpf-2 Dipeptidyl peptidase family member 2 [ Caenorhabditis elegans ]

    Gene ID: 181579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpf-2
    Official Full Name
    Dipeptidyl peptidase family member 2
    Primary source
    WormBase:WBGene00001055
    Locus tag
    CELE_C27C12.7
    See related
    AllianceGenome:WB:WBGene00001055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in head; head mesodermal cell; non-striated muscle; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to several human genes including FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpf-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    17
    Sequence:
    Chromosome: X; NC_003284.9 (14831831..14838191)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Early growth response factor homolog 1 Neighboring gene DEgenerin Like Neighboring gene E3 ubiquitin-protein ligase LIN-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dipeptidyl peptidase family member 2
    NP_510461.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14831831..14838191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078060.11 → NP_510461.1  Dipeptidyl peptidase family member 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18253
      Conserved Domains (3) summary
      COG1073
      Location:567 → 817
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
      pfam00326
      Location:623 → 801
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:152 → 536
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18253.1

    Gene LinkOut

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