bbs-2 BBSome complex member bbs-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bbs-2
Official Full Name: BBSome complex member bbs-2
Primary source: WormBase:WBGene00000242
Locus tag: CELE_F20D12.3
See related: AllianceGenome:WB:WBGene00000242
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in non-motile cilium assembly. Located in ciliary basal body and neuron projection. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 2; obesity; and retinitis pigmentosa 74. Orthologous to human BBS2 (Bardet-Biedl syndrome 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bbs-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (7934033..7937749)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20D12.3 (e-PCR)
- UniSTS:314090

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	IEA Inferred from Electronic Annotation more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in motile cilium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BBSome complex member bbs-2

NP_501325.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7934033..7937749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068924.3 → NP_501325.2 BBSome complex member bbs-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501325.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19640

Conserved Domains (3) summary

pfam14781
Location:76 → 165

BBS2_N; Ciliary BBSome complex subunit 2, N-terminal

pfam14782
Location:298 → 709

BBS2_C; Ciliary BBSome complex subunit 2, C-terminal

pfam14783
Location:167 → 272

BBS2_Mid; Ciliary BBSome complex subunit 2, middle region