erh-2 Enhancer of rudimentary homolog 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: erh-2
Official Full Name: Enhancer of rudimentary homolog 2
Primary source: WormBase:WBGene00009444
Locus tag: CELE_F35G12.11
See related: AllianceGenome:WB:WBGene00009444
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in piRNA processing; positive regulation of cell division; and positive regulation of chromosome segregation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in germ line. Orthologous to human ERH (ERH mRNA splicing and mitosis factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See erh-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (4593231..4593827)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35G12.8 (e-PCR)
- UniSTS:321438

F35G12.11 (e-PCR)
- UniSTS:320720

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Enhancer of rudimentary homolog 2

NP_497936.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4593231..4593827

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065535.8 → NP_497936.2 Enhancer of rudimentary homolog 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497936.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20057

Conserved Domains (1) summary

pfam01133
Location:5 → 100

ER; Enhancer of rudimentary