U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    grdn-1 Girdin homolog [ Caenorhabditis elegans ]

    Gene ID: 190137, updated on 9-Dec-2024

    Summary

    Official Symbol
    grdn-1
    Official Full Name
    Girdin homolog
    Primary source
    WormBase:WBGene00013082
    Locus tag
    CELE_Y51A2D.15
    See related
    AllianceGenome:WB:WBGene00013082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein light intermediate chain binding activity and microtubule binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell projection organization; and positive regulation of dendrite extension. Located in centriole and ciliary basal body. Is expressed in sensory neurons. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to several human genes including CCDC88A (coiled-coil domain containing 88A) and CCDC88C (coiled-coil domain containing 88C). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See grdn-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    20
    Sequence:
    Chromosome: V; NC_003283.11 (18592748..18614135)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene transcellular chaperone signaling (x)cross tissue Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nuclear Hormone Receptor family Neighboring gene Serpentine Receptor, class V;Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dynein light intermediate chain binding  
    enables microtubule binding  
    Component Evidence Code Pubs
    located_in cell projection  
    located_in centriole PubMed 
    located_in centriole  
    is_active_in centrosome  
    located_in ciliary basal body PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  

    General protein information

    Preferred Names
    Girdin homolog
    NP_001256816.1
    • Confirmed by transcript evidence
    NP_001256818.1
    • Confirmed by transcript evidence
    NP_001359512.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18592748..18614135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269887.4 → NP_001256816.1  Girdin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256816.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3Y5P4, F3Y5P5, Q9XXR1
      Conserved Domains (1) summary
      cl25732
      Location:281 → 1083
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001373186.2 → NP_001359512.1  Girdin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG1196
      Location:281 → 1083
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. NM_001269889.3 → NP_001256818.1  Girdin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3Y5P4
      Conserved Domains (1) summary
      COG1196
      Location:115 → 917
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    External link. Please review our privacy policy.