mtr-4 mRNA transport homolog 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtr-4
Official Full Name: mRNA transport homolog 4
Primary source: WormBase:WBGene00012342
Locus tag: CELE_W08D2.7
See related: AllianceGenome:WB:WBGene00012342
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA helicase activity. Predicted to be involved in RNA catabolic process and maturation of 5.8S rRNA. Predicted to be located in nucleus. Predicted to be part of TRAMP complex. Is expressed in several structures, including PVD; germ line; intestine; pharynx; and somatic cell. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtr-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 18

Sequence:: Chromosome: IV; NC_003282.8 (9825694..9830620)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans.
Title: A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08D2.7 (e-PCR)
- UniSTS:311156

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TRAMP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA transport homolog 4

NP_501757.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9825694..9830620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069356.6 → NP_501757.1 mRNA transport homolog 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501757.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23223

Conserved Domains (5) summary

smart00490
Location:427 → 515

HELICc; helicase superfamily c-terminal domain

COG4581
Location:97 → 1026

Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

pfam00270
Location:130 → 273

DEAD; DEAD/DEAH box helicase

pfam08148
Location:857 → 1019

DSHCT; DSHCT (NUC185) domain

pfam13234
Location:571 → 825

rRNA_proc-arch; rRNA-processing arch domain