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    mab-5 Homeobox protein mab-5 [ Caenorhabditis elegans ]

    Gene ID: 176091, updated on 9-Dec-2024

    Summary

    Official Symbol
    mab-5
    Official Full Name
    Homeobox protein mab-5
    Primary source
    WormBase:WBGene00003102
    Locus tag
    CELE_C08C3.3
    See related
    AllianceGenome:WB:WBGene00003102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuroblast migration; positive regulation of mesodermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including body ganglion; body wall musculature; male-specific anatomical entity; neurons; and vulval cell. Orthologous to several human genes including HOXB8 (homeobox B8) and HOXC8 (homeobox C8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mab-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (7776835..7783454, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene BTB and MATH domain-containing protein 15;BTB domain-containing protein Neighboring gene Cytokinesis defective protein 7 Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex PubMed 
    is_active_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Homeobox protein mab-5
    NP_498695.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7776835..7783454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066294.8 → NP_498695.1  Homeobox protein mab-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10038, Q9GZ02
      Conserved Domains (1) summary
      pfam00046
      Location:120 → 173
      Homeobox; Homeobox domain
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