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    EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B [ Homo sapiens (human) ]

    Gene ID: 255308, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF2S3Bprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2 subunit gamma Bprovided by HGNC
    Primary source
    HGNC:HGNC:43863
    See related
    Ensembl:ENSG00000180574 AllianceGenome:HGNC:43863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eIF2gA; EIF2S3L; eIF-2gA
    Summary
    Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to be part of eukaryotic translation initiation factor 2 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EIF2S3B in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10505890..10523135)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10377306..10394552)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10658489..10675734)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor C2 Neighboring gene killer cell lectin like receptor C1 Neighboring gene uncharacterized LOC105369657 Neighboring gene uncharacterized LOC105369658 Neighboring gene SLC25A39 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Emergence of young human genes after a burst of retroposition in primates. Marques AC, et al. PLoS Biol, 2005 Nov. PMID 16201836, Free PMC Article
    2. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
    3. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article
    4. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Tan P, et al. Mol Cell, 2017 Oct 19. PMID 29053956
    5. Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant. Matos AM, et al. J Biol Chem, 2019 Sep 6. PMID 31324722, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3B
    Names
    eIF-2-gamma2
    eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
    putative eukaryotic translation initiation factor 2 subunit 3-like protein
    NP_001344660.1
    NP_001344663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357731.1 → NP_001344660.1  eukaryotic translation initiation factor 2 subunit 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068775, BC087847, DB461648
      Consensus CDS
      CCDS86282.1
      Related
      ENSP00000323063.3, ENST00000322446.3
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 438
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    2. NM_001357734.3 → NP_001344663.1  eukaryotic translation initiation factor 2 subunit 3B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068775
      Consensus CDS
      CCDS91654.1
      UniProtKB/Swiss-Prot
      F8W810, Q2VIR3, Q5I0X0, Q6KF84
      Related
      ENSP00000445077.1, ENST00000538173.2
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10505890..10523135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10377306..10394552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_003215.3: Suppressed sequence

      Description
      NG_003215.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2VIR3.2 GenPept UniProtKB/Swiss-Prot:Q2VIR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials