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    Dgkg diacylglycerol kinase, gamma [ Mus musculus (house mouse) ]

    Gene ID: 110197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dgkgprovided by MGI
    Official Full Name
    diacylglycerol kinase, gammaprovided by MGI
    Primary source
    MGI:MGI:105060
    See related
    Ensembl:ENSMUSG00000022861 AllianceGenome:MGI:105060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    90kDa; Dagk3; mKIAA4131; 2900055E17Rik; E430001K23Rik
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and negative regulation of phospholipase C/protein kinase C signal transduction. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Orthologous to human DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.5), frontal lobe adult (RPKM 4.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dgkg in Genome Data Viewer
    Location:
    16 B1; 16 13.37 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22285318..22476051, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22466568..22657302, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40391 Neighboring gene STARR-seq mESC enhancer starr_40392 Neighboring gene STARR-seq mESC enhancer starr_40393 Neighboring gene G protein subunit gamma 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40394 Neighboring gene STARR-seq mESC enhancer starr_40398 Neighboring gene STARR-seq mESC enhancer starr_40399 Neighboring gene STARR-seq mESC enhancer starr_40400 Neighboring gene STARR-seq mESC enhancer starr_40406 Neighboring gene ets variant 5 Neighboring gene STARR-positive B cell enhancer ABC_E394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:22498212-22498365 Neighboring gene RIKEN cDNA 9230117E06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:22545025-22545325 Neighboring gene mitochondrial import inner membrane translocase subunit Tim21 pseudogene Neighboring gene microRNA 8095 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene predicted gene 15651 Neighboring gene STARR-seq mESC enhancer starr_40415 Neighboring gene STARR-seq mESC enhancer starr_40416 Neighboring gene predicted gene, 41433 Neighboring gene STARR-positive B cell enhancer mm9_chr16:22633282-22633583 Neighboring gene STARR-seq mESC enhancer starr_40417 Neighboring gene microRNA 6362 Neighboring gene STARR-positive B cell enhancer ABC_E5532 Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 30416 Neighboring gene crystallin, gamma S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ. Tsumagari R, et al. eNeuro, 2020 Mar/Apr. PMID 32033984, Free PMC Article
    2. Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ. Tanino F, et al. Mol Cell Biochem, 2013 Jan. PMID 23054194
    3. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma. Zhang L, et al. J Hepatol, 2024 Jan. PMID 37838036
    4. Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior. Isozaki T, et al. J Neurochem, 2016 Aug. PMID 27167678
    5. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. Yasuda S, et al. FEBS Lett, 2007 Feb 6. PMID 17254573

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.
      Title: Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.
    2. DGKgamma Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCgamma.
      Title: DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ.
    3. Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is Crucial for Motor Coordination.
      Title: Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.
    4. A novel morphological function of the C-terminal DGK-gamma catalytic region in filopodia formation, independent of its enzymatic activity.
      Title: Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ.
    5. DGKgamma functions through its catalytic action as an upstream suppressor of Rac1 and has a role in lamellipodium/ruffle formation
      Title: Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phospholipase C/protein kinase C signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase gamma
    Names
    88 kDa diacylglycerol kinase
    DAG kinase gamma
    DGK-gamma
    diacylglycerol kinase, gamma 3
    diacylglycerol kinase, gamma 90kDa
    diglyceride kinase gamma
    NP_001333602.1
    NP_619591.1
    XP_017172339.1
    XP_017172340.1
    XP_017172341.1
    XP_036015627.1
    XP_036015628.1
    XP_036015629.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346673.1 → NP_001333602.1  diacylglycerol kinase gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI646503, AK083258, BB653405, BY724037, CT009627
      Consensus CDS
      CCDS84217.1
      UniProtKB/TrEMBL
      Q570Z5, Q8C413
      Related
      ENSMUSP00000023578.8, ENSMUST00000023578.14

    2. NM_138650.2 → NP_619591.1  diacylglycerol kinase gamma isoform 1

      See identical proteins and their annotated locations for NP_619591.1

      Status: VALIDATED

      Source sequence(s)
      AK013697, AK220294, BU700613, BY724037
      Consensus CDS
      CCDS28068.1
      UniProtKB/Swiss-Prot
      Q91WG7
      UniProtKB/TrEMBL
      Q570Z5
      Related
      ENSMUSP00000087371.4, ENSMUST00000089925.10
      Conserved Domains (8) summary
      TIGR00147
      Location:433 → 753
      TIGR00147; lipid kinase, YegS/Rv2252/BmrU family
      smart00109
      Location:333 → 374
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:575 → 749
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433 → 554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:269 → 318
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:176 → 245
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:177 → 241
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:5 → 172
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22285318..22476051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316851.3 → XP_017172340.1  diacylglycerol kinase gamma isoform X2

      UniProtKB/TrEMBL
      Q570Z5
      Conserved Domains (5) summary
      smart00045
      Location:582 → 756
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:315 → 364
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:176 → 291
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 172
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_017316850.3 → XP_017172339.1  diacylglycerol kinase gamma isoform X1

      UniProtKB/TrEMBL
      Q570Z5
      Conserved Domains (6) summary
      smart00109
      Location:379 → 420
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:621 → 795
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:479 → 600
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:315 → 364
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:176 → 291
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 172
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. XM_036159736.1 → XP_036015629.1  diacylglycerol kinase gamma isoform X6

      Conserved Domains (4) summary
      smart00045
      Location:340 → 514
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:198 → 319
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:56 → 129
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl08302
      Location:15 → 49
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_036159735.1 → XP_036015628.1  diacylglycerol kinase gamma isoform X5

      Conserved Domains (4) summary
      smart00045
      Location:379 → 553
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:237 → 358
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:56 → 129
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl08302
      Location:15 → 49
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. XM_036159734.1 → XP_036015627.1  diacylglycerol kinase gamma isoform X4

      Conserved Domains (4) summary
      smart00045
      Location:425 → 599
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:283 → 404
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:102 → 175
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl08302
      Location:64 → 95
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. XM_017316852.3 → XP_017172341.1  diacylglycerol kinase gamma isoform X3

      UniProtKB/TrEMBL
      Q570Z5
      Conserved Domains (6) summary
      smart00109
      Location:379 → 420
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:479 → 600
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:315 → 364
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:176 → 291
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:5 → 172
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl02440
      Location:621 → 743
      DAGK_acc; Diacylglycerol kinase accessory domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WG7.1 GenPept UniProtKB/Swiss-Prot:Q91WG7

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