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    SEC24C SEC24 homolog C, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 9632, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SEC24Cprovided by HGNC
    Official Full Name
    SEC24 homolog C, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:10705
    See related
    Ensembl:ENSG00000176986 MIM:607185; AllianceGenome:HGNC:10705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC24C in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73744372..73772161)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74615788..74643577)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75504130..75531919)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75491691-75492411 Neighboring gene glutamate dehydrogenase 1 pseudogene 3 Neighboring gene dual specificity phosphatase 8 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75500671-75501238 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:75501239-75501806 Neighboring gene uncharacterized LOC124902453 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:75503472-75504671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75532921-75533451 Neighboring gene fucosyltransferase 11 Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. Sucic S, et al. J Biol Chem, 2013 Feb 22. PMID 23288844, Free PMC Article
    2. Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. Tani K, et al. FEBS Lett, 1999 Mar 26. PMID 10214955
    3. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Rebensburg SV, et al. Nat Microbiol, 2021 Apr. PMID 33649557, Free PMC Article
    4. Selective export of autotaxin from the endoplasmic reticulum. Lyu L, et al. J Biol Chem, 2017 Apr 28. PMID 28298439, Free PMC Article
    5. Regulation of a COPII component by cytosolic O-glycosylation during mitosis. Dudognon P, et al. FEBS Lett, 2004 Mar 12. PMID 15013749

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sec24C is an HIV-1 host dependency factor crucial for virus replication.
      Title: Sec24C is an HIV-1 host dependency factor crucial for virus replication.
    2. The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.
      Title: The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.
    3. These data suggest that SEC24C is a major cargo adapter for COPII-dependent transport in postmitotic neurons in developing and adult brains and that its functions overlap at least partially with those of SEC24D in mammals.
      Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
    4. Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system.
      Title: Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry.
    5. AKT signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell-mediated p23 (Sec24C) expression
      Title: Selective export of autotaxin from the endoplasmic reticulum.
    6. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C.
      Title: A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.
    7. a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C
      Title: Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.
    8. A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export
      Title: A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.
    9. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
      Title: The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.
    10. We found that Sec24C, a component of the host COPII vesicular transport system, interacts specifically with VP40 via VP40 amino acids 303 to 307.
      Title: Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0079

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPII vesicle coat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec24C
    Names
    SEC24 family, member C
    SEC24 related gene family, member C
    SEC24-related protein C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004922.4 → NP_004913.2  protein transport protein Sec24C

      See identical proteins and their annotated locations for NP_004913.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022400, AL596994, BQ710971, CA419040, D38555
      Consensus CDS
      CCDS7332.1
      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31
      Related
      ENSP00000343405.2, ENST00000339365.2
      Conserved Domains (9) summary
      COG5028
      Location:181 → 1090
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:499 → 758
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:961 → 1036
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:422 → 459
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:847 → 943
      Sec23_helical; Sec23/Sec24 helical domain
      pfam04959
      Location:221 → 306
      ARS2; Arsenite-resistance protein 2
      pfam07001
      Location:142 → 248
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:748 → 831
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11 → 105
      Gly-rich_Ago1; Glycine-rich region of argonaut

    2. NM_198597.3 → NP_940999.1  protein transport protein Sec24C

      See identical proteins and their annotated locations for NP_940999.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022400, AL596994, BC018928, CA419040, D38555
      Consensus CDS
      CCDS7332.1
      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31
      Related
      ENSP00000321845.6, ENST00000345254.9
      Conserved Domains (9) summary
      COG5028
      Location:181 → 1090
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:499 → 758
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:961 → 1036
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:422 → 459
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:847 → 943
      Sec23_helical; Sec23/Sec24 helical domain
      pfam04959
      Location:221 → 306
      ARS2; Arsenite-resistance protein 2
      pfam07001
      Location:142 → 248
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:748 → 831
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11 → 105
      Gly-rich_Ago1; Glycine-rich region of argonaut

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73744372..73772161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426032.1 → XP_047281988.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      G5EA31

    2. XM_047426033.1 → XP_047281989.1  protein transport protein Sec24C isoform X2

      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31

    3. XM_047426031.1 → XP_047281987.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      G5EA31

    4. XM_047426034.1 → XP_047281990.1  protein transport protein Sec24C isoform X2

      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31

    5. XM_011540381.4 → XP_011538683.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_011538683.1

      UniProtKB/TrEMBL
      G5EA31
      Conserved Domains (8) summary
      COG5028
      Location:323 → 1113
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:522 → 781
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:984 → 1059
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:445 → 482
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:870 → 966
      Sec23_helical; Sec23/Sec24 helical domain
      pfam07001
      Location:142 → 240
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:771 → 854
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11 → 105
      Gly-rich_Ago1; Glycine-rich region of argonaut

    6. XM_011540380.4 → XP_011538682.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_011538682.1

      UniProtKB/TrEMBL
      G5EA31
      Conserved Domains (8) summary
      COG5028
      Location:323 → 1113
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:522 → 781
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:984 → 1059
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:445 → 482
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:870 → 966
      Sec23_helical; Sec23/Sec24 helical domain
      pfam07001
      Location:142 → 240
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:771 → 854
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11 → 105
      Gly-rich_Ago1; Glycine-rich region of argonaut

    7. XM_047426035.1 → XP_047281991.1  protein transport protein Sec24C isoform X3

      UniProtKB/TrEMBL
      B4DSN3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74615788..74643577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367227.1 → XP_054223202.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      G5EA31

    2. XM_054367226.1 → XP_054223201.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      G5EA31

    3. XM_054367229.1 → XP_054223204.1  protein transport protein Sec24C isoform X2

      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31

    4. XM_054367230.1 → XP_054223205.1  protein transport protein Sec24C isoform X2

      UniProtKB/Swiss-Prot
      B4DZT4, P53992, Q8WV25
      UniProtKB/TrEMBL
      G5EA31

    5. XM_054367228.1 → XP_054223203.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      G5EA31

    6. XM_054367231.1 → XP_054223206.1  protein transport protein Sec24C isoform X3

      UniProtKB/TrEMBL
      B4DSN3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53992.3 GenPept UniProtKB/Swiss-Prot:P53992

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