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    STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

    Gene ID: 11329, updated on 27-Nov-2024

    Summary

    Official Symbol
    STK38provided by HGNC
    Official Full Name
    serine/threonine kinase 38provided by HGNC
    Primary source
    HGNC:HGNC:17847
    See related
    Ensembl:ENSG00000112079 MIM:606964; AllianceGenome:HGNC:17847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDR; NDR1
    Summary
    This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STK38 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36493892..36547479, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36314555..36368143, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461669..36515256, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17114 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24427 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24429 Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene uncharacterized LOC124901558 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36514791-36515314 Neighboring gene MPRA-validated peak5783 silencer Neighboring gene MPRA-validated peak5784 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36544382-36545325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36561915-36562596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564442-36564942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564943-36565443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567225-36567726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567727-36568226 Neighboring gene MPRA-validated peak5786 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24432 Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables UFM1-modified protein reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like protein reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase 38
    Names
    NDR1 protein kinase
    Ndr Ser/Thr kinase-like protein
    nuclear Dbf2-related kinase 1
    NP_001292031.1
    NP_009202.1
    XP_016865715.1
    XP_047274095.1
    XP_047274096.1
    XP_047274097.1
    XP_047274098.1
    XP_047274099.1
    XP_047274100.1
    XP_054210120.1
    XP_054210121.1
    XP_054210122.1
    XP_054210123.1
    XP_054210124.1
    XP_054210125.1
    XP_054210126.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305102.2NP_001292031.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_001292031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, BC095413, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208, Q503A1
      UniProtKB/TrEMBL
      B2R6F9
      Conserved Domains (1) summary
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
    2. NM_007271.4NP_009202.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_009202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208, Q503A1
      UniProtKB/TrEMBL
      B2R6F9
      Related
      ENSP00000229812.7, ENST00000229812.8
      Conserved Domains (1) summary
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36493892..36547479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010226.2XP_016865715.1  serine/threonine-protein kinase 38 isoform X2

      UniProtKB/TrEMBL
      B2R6F9
      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:87424
      PKc_like; Protein Kinases, catalytic domain
    2. XM_047418142.1XP_047274098.1  serine/threonine-protein kinase 38 isoform X2

    3. XM_047418140.1XP_047274096.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    4. XM_047418143.1XP_047274099.1  serine/threonine-protein kinase 38 isoform X2

    5. XM_047418141.1XP_047274097.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    6. XM_047418139.1XP_047274095.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    7. XM_047418144.1XP_047274100.1  serine/threonine-protein kinase 38 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      36314555..36368143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354149.1XP_054210124.1  serine/threonine-protein kinase 38 isoform X2

    2. XM_054354148.1XP_054210123.1  serine/threonine-protein kinase 38 isoform X2

    3. XM_054354146.1XP_054210121.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    4. XM_054354150.1XP_054210125.1  serine/threonine-protein kinase 38 isoform X2

    5. XM_054354147.1XP_054210122.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    6. XM_054354145.1XP_054210120.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q15208, Q503A1
    7. XM_054354151.1XP_054210126.1  serine/threonine-protein kinase 38 isoform X3