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    Prkn parkin RBR E3 ubiquitin protein ligase [ Mastomys coucha (southern multimammate mouse) ]

    Gene ID: 116076805, updated on 18-Mar-2024

    Summary

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    Gene symbol
    Prkn
    Gene description
    parkin RBR E3 ubiquitin protein ligase
    See related
    EnsemblRapid:ENSMCUG00000004633
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mastomys coucha
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mastomys
    Orthologs
    human mouse all
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    Genomic context

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    See Prkn in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    100 current UCSF_Mcou_1 (GCF_008632895.1) Unplaced Scaffold NW_022196911.1 (9168755..10407405, complement)

    NW_022196911.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform pseudogene Neighboring gene uncharacterized LOC116078967 Neighboring gene U7 small nuclear RNA Neighboring gene arginine/serine-rich coiled-coil protein 2-like Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene 60S ribosomal protein L19-like Neighboring gene uncharacterized LOC116076810 Neighboring gene parkin coregulated Neighboring gene uncharacterized LOC116076809 Neighboring gene QKI, KH domain containing RNA binding

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_022196911 Unplaced Scaffold Reference UCSF_Mcou_1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase parkin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Mastomys coucha Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCSF_Mcou_1 Primary Assembly

    Genomic

    1. NW_022196911.1 Reference UCSF_Mcou_1 Primary Assembly

      Range
      9168755..10407405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031350750.1 → XP_031206610.1  E3 ubiquitin-protein ligase parkin isoform X2

      Conserved Domains (5) summary
      smart00647
      Location:312 → 374
      IBR; In Between Ring fingers
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:412 → 452
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:144 → 216
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:227 → 317
      zf-RING_14; RING/Ubox like zinc-binding domain

    2. XM_031350749.1 → XP_031206609.1  E3 ubiquitin-protein ligase parkin isoform X1

      Related
      ENSMCUP00000005295.1, ENSMCUT00000006708.1
      Conserved Domains (5) summary
      smart00647
      Location:313 → 375
      IBR; In Between Ring fingers
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:413 → 453
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 318
      zf-RING_14; RING/Ubox like zinc-binding domain

    3. XM_031350751.1 → XP_031206611.1  E3 ubiquitin-protein ligase parkin isoform X3

      Conserved Domains (5) summary
      smart00647
      Location:311 → 373
      IBR; In Between Ring fingers
      cd01798
      Location:2 → 74
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:411 → 451
      IBR; IBR domain, a half RING-finger domain
      pfam17976
      Location:143 → 215
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:226 → 316
      zf-RING_14; RING/Ubox like zinc-binding domain

    4. XM_031350752.1 → XP_031206612.1  E3 ubiquitin-protein ligase parkin isoform X4

      Conserved Domains (4) summary
      smart00647
      Location:313 → 375
      IBR; In Between Ring fingers
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 318
      zf-RING_14; RING/Ubox like zinc-binding domain

    5. XM_031350754.1 → XP_031206614.1  E3 ubiquitin-protein ligase parkin isoform X6

    6. XM_031350753.1 → XP_031206613.1  E3 ubiquitin-protein ligase parkin isoform X5

      Conserved Domains (3) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 290
      zf-RING_14; RING/Ubox like zinc-binding domain

    7. XM_031350756.1 → XP_031206616.1  E3 ubiquitin-protein ligase parkin isoform X8

      Conserved Domains (3) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 246
      zf-RING_14; RING/Ubox like zinc-binding domain

    8. XM_031350755.1 → XP_031206615.1  E3 ubiquitin-protein ligase parkin isoform X7

      Conserved Domains (3) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 245
      zf-RING_14; RING/Ubox like zinc-binding domain
    Nucleotide Protein
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