afd-1 Afadin;FHA domain-containing protein;PDZ domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: afd-1
Official Full Name: Afadin;FHA domain-containing protein;PDZ domain-containing protein
Primary source: WormBase:WBGene00021009
Locus tag: CELE_W03F11.6
See related: AllianceGenome:WB:WBGene00021009
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in regulation of protein localization. Predicted to be located in cell-cell junction. Predicted to be active in adherens junction. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See afd-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 23

Sequence:: Chromosome: I; NC_003279.8 (2160038..2209644)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21.
Title: C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W03F11.6 (e-PCR)
- UniSTS:311111

Y39G10A_236.c (e-PCR)
- UniSTS:324308

Y39G10A_236.d (e-PCR)
- UniSTS:322807

Y39G10A_236.e (e-PCR)
- UniSTS:322808

Y39G10A_236.b (e-PCR)
- UniSTS:324603

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Afadin;FHA domain-containing protein;PDZ domain-containing protein

NP_001021659.1

Confirmed by transcript evidence

NP_001021660.2

Confirmed by transcript evidence

NP_001021661.2

Confirmed by transcript evidence

NP_001293329.1

Confirmed by transcript evidence

NP_001293330.1

Confirmed by transcript evidence

NP_001293331.1

Confirmed by transcript evidence

NP_001293332.1

Confirmed by transcript evidence

NP_001293333.1

Confirmed by transcript evidence

NP_001293334.1

Confirmed by transcript evidence

NP_001293335.1

Confirmed by transcript evidence

NP_001293336.1

Confirmed by transcript evidence

NP_001293337.1

Confirmed by transcript evidence

NP_001293458.1

Confirmed by transcript evidence

NP_001343732.1

Confirmed by transcript evidence

NP_490938.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2160038..2209644

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026490.6 → NP_001021661.2 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021661.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86NJ3, Q9XY66

Conserved Domains (5) summary

cd00992
Location:971 → 1052

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:564 → 865

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01782
Location:15 → 126

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00788
Location:215 → 319

RA; Ras association (RalGDS/AF-6) domain

cl00062
Location:352 → 453

FHA; forkhead associated (FHA) domain superfamily
NM_001306400.4 → NP_001293329.1 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293329.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XY66, X5LPT9

Conserved Domains (5) summary

cd00992
Location:973 → 1054

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:566 → 867

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01782
Location:15 → 126

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00788
Location:217 → 321

RA; Ras association (RalGDS/AF-6) domain

cl00062
Location:354 → 455

FHA; forkhead associated (FHA) domain superfamily
NM_058537.5 → NP_490938.3 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490938.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9BIC1, Q9N400, Q9XY66

Conserved Domains (6) summary

cd00060
Location:352 → 455

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:971 → 1052

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:564 → 865

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01782
Location:15 → 126

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00788
Location:219 → 319

RA; Ras association (RalGDS/AF-6) domain

pfam11702
Location:1172 → 1238

DUF3295; Protein of unknown function (DUF3295)
NM_001026489.8 → NP_001021660.2 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021660.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86NJ4, Q9XY66

Conserved Domains (5) summary

cd00992
Location:973 → 1054

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:566 → 867

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01782
Location:15 → 126

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00788
Location:217 → 321

RA; Ras association (RalGDS/AF-6) domain

cl00062
Location:354 → 455

FHA; forkhead associated (FHA) domain superfamily
NM_001356800.4 → NP_001343732.1 FHA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C357, Q9XY66

Conserved Domains (4) summary

cd00060
Location:192 → 295

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:811 → 892

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:404 → 705

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam11702
Location:1012 → 1078

DUF3295; Protein of unknown function (DUF3295)
NM_001306401.3 → NP_001293330.1 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293330.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XY66, X5LX70

Conserved Domains (3) summary

cd00992
Location:695 → 776

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:288 → 589

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cl00062
Location:76 → 177

FHA; forkhead associated (FHA) domain superfamily
NM_001306402.3 → NP_001293331.1 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293331.1

Status: REVIEWED

UniProtKB/TrEMBL

X5M5P8

Conserved Domains (3) summary

cd00992
Location:695 → 776

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:288 → 589

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cl00062
Location:76 → 177

FHA; forkhead associated (FHA) domain superfamily
NM_001306403.3 → NP_001293332.1 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293332.1

Status: REVIEWED

UniProtKB/TrEMBL

X5M8U5

Conserved Domains (3) summary

cd00992
Location:633 → 714

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:226 → 527

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cl00062
Location:14 → 115

FHA; forkhead associated (FHA) domain superfamily
NM_001306404.3 → NP_001293333.1 Afadin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293333.1

Status: REVIEWED

UniProtKB/TrEMBL

X5LV54

Conserved Domains (3) summary

cd00992
Location:633 → 714

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:226 → 527

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cl00062
Location:14 → 115

FHA; forkhead associated (FHA) domain superfamily
NM_001306405.3 → NP_001293334.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293334.1

Status: REVIEWED

UniProtKB/TrEMBL

X5LPU4

Conserved Domains (2) summary

cd00992
Location:540 → 621

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:133 → 434

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
NM_001306406.3 → NP_001293335.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293335.1

Status: REVIEWED

UniProtKB/TrEMBL

X5LX73

Conserved Domains (2) summary

cd00992
Location:540 → 621

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:133 → 434

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
NM_001306529.4 → NP_001293458.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293458.1

Status: REVIEWED

UniProtKB/TrEMBL

M1ZJY5

Conserved Domains (3) summary

cd00992
Location:565 → 646

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:158 → 459

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam11702
Location:766 → 832

DUF3295; Protein of unknown function (DUF3295)
NM_001306407.3 → NP_001293336.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293336.1

Status: REVIEWED

UniProtKB/TrEMBL

X5M5Q5

Conserved Domains (2) summary

cd00992
Location:458 → 539

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:51 → 352

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
NM_001306408.3 → NP_001293337.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293337.1

Status: REVIEWED

UniProtKB/TrEMBL

X5M8V1

Conserved Domains (2) summary

cd00992
Location:458 → 539

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15471
Location:51 → 352

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
NM_001026488.5 → NP_001021659.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021659.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9BIC0

Conserved Domains (1) summary

cd00992
Location:8 → 72

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...