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    skpt-1 F-box domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skpt-1
    Official Full Name
    F-box domain-containing protein
    Primary source
    WormBase:WBGene00018613
    Locus tag
    CELE_F48E8.7
    See related
    AllianceGenome:WB:WBGene00018613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skpt-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (5446511..5448395, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DM2 domain-containing protein Neighboring gene DIS3-like exonuclease 2 Neighboring gene Hsp20/alpha crystallin family protein Neighboring gene putative serine/threonine-protein phosphatase PP2A regulatory subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Kim Y, et al. Mol Cell Biol, 2007 Feb. PMID 17145765, Free PMC Article
    2. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka A, et al. Curr Biol, 2002 Feb 19. PMID 11864566
    3. The F-box protein family. Kipreos ET, et al. Genome Biol, 2000. PMID 11178263, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box domain-containing protein
    NP_741136.1
    • Confirmed by transcript evidence
    NP_741137.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5446511..5448395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171121.5 → NP_741136.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741136.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ34
      Conserved Domains (3) summary
      cd09293
      Location:147 → 370
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:150 → 180
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:89 → 127
      F-box-like

    2. NM_171865.7 → NP_741137.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09397
      Conserved Domains (3) summary
      cd09293
      Location:150 → 373
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:153 → 183
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:92 → 130
      F-box-like
    Nucleotide Protein
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