Zfp35 zinc finger protein 35 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp35provided by MGI
Official Full Name: zinc finger protein 35provided by MGI
Primary source: MGI:MGI:99179
See related: Ensembl:ENSMUSG00000063281 AllianceGenome:MGI:99179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp-35; Znf271; mszf13; mszf28; mszf68; mszf20-1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within inflammatory response to antigenic stimulus and negative regulation of T-helper 2 cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including bladder; central nervous system; early conceptus; and gonad. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 4.4), CNS E11.5 (RPKM 3.4) and 20 other tissues See more
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Genomic context

Location:: 18 A2; 18 12.51 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (24122134..24138428)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (23989634..24005371)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zfp35 may control Th2-dependent diseases, such as allergic asthma.
Title: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011755.2 → NP_035885.2 zinc finger protein 271

See identical proteins and their annotated locations for NP_035885.2

Status: VALIDATED

Source sequence(s)

AC126807, BB614371

Consensus CDS

CCDS29097.1

UniProtKB/Swiss-Prot

P15620

UniProtKB/TrEMBL

Q3V142

Related

ENSMUSP00000074475.8, ENSMUST00000074941.8

Conserved Domains (3) summary

COG5048
Location:102 → 489

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:106 → 126

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:541 → 562

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

24122134..24138428

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161135.1 → XP_036017028.1 zinc finger protein 271 isoform X1

UniProtKB/Swiss-Prot

P15620

UniProtKB/TrEMBL

Q3V142

Conserved Domains (3) summary

COG5048
Location:102 → 489

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:106 → 126

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:541 → 562

zf-H2C2_2; Zinc-finger double domain