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    pat-12 Protein pat-12 [ Caenorhabditis elegans ]

    Gene ID: 175227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pat-12
    Official Full Name
    Protein pat-12
    Primary source
    WormBase:WBGene00003936
    Locus tag
    CELE_T17H7.4
    See related
    AllianceGenome:WB:WBGene00003936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Is expressed in hypodermis; neurons; pharynx; rectum; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pat-12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    29
    Sequence:
    Chromosome: III; NC_003281.10 (727207..752426, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein Neighboring gene ncRNA Neighboring gene VPSAGDMMVRF-amide Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Mucin-5AC Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. Hetherington S, et al. Dev Biol, 2011 Feb 15. PMID 21130760
    2. Silencing of essential genes by RNA interference in Haemonchus contortus. Zawadzki JL, et al. Parasitology, 2012 Apr. PMID 22348596
    3. Induction of protective response to polystyrene nanoparticles associated with methylation regulation in Caenorhabditis elegans. Wang S, et al. Chemosphere, 2021 May. PMID 33453486
    4. Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5. Fisk Green R, et al. Mol Genet Genomics, 2004 Jun. PMID 15138888
    5. Predicting aging/longevity-related genes in the nematode Caenorhabditis elegans. Witten TM, et al. Chem Biodivers, 2007 Nov. PMID 18027377

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAT-12 defines a novel component of C. elegans hemidesmosomes, which is required for maintaining their integrity
      Title: PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemidesmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein pat-12
    NP_001359886.1
    • Confirmed by transcript evidence
    NP_001367549.1
    • Confirmed by transcript evidence
    NP_001367550.1
    • Confirmed by transcript evidence
    NP_001367551.1
    • Confirmed by transcript evidence
    NP_001367552.1
    • Confirmed by transcript evidence
    NP_001367554.1
    • Confirmed by transcript evidence
    NP_001367555.1
    • Confirmed by transcript evidence
    NP_001368692.1
    • Confirmed by transcript evidence
    NP_001379711.1
    • Partially confirmed by transcript evidence
    NP_741076.1
    • Confirmed by transcript evidence
    NP_741077.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      727207..752426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381698.1 → NP_001367550.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_001381703.2 → NP_001367552.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    3. NM_171067.5 → NP_741076.1  Protein pat-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QA6

    4. NM_171068.5 → NP_741077.1  Protein pat-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QA6

    5. NM_001393260.1 → NP_001379711.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PHA03307
      Location:891 → 1028
      PHA03307; transcriptional regulator ICP4; Provisional

    6. NM_001381699.1 → NP_001367549.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KYY3, H2KYY4, H2KYY5, H2KYY6, H2KYY7, H2KYY8, H2KYY9, H2KYZ0, H2KYZ1, H2KYZ2, Q8MPW4, Q95QA6

    7. NM_001373834.2 → NP_001359886.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    8. NM_001381702.2 → NP_001367555.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    9. NM_001381700.1 → NP_001367551.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    10. NM_001381701.2 → NP_001367554.1  Protein pat-12 [Caenorhabditis elegans]

      Status: REVIEWED

    11. NM_001381705.1 → NP_001368692.1  Protein pat-12, partial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5ATV2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95QA6.1

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