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    pges-2 Prostaglandin E synthase 2 [ Caenorhabditis elegans ]

    Gene ID: 177925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pges-2
    Official Full Name
    Prostaglandin E synthase 2
    Primary source
    WormBase:WBGene00011239
    Locus tag
    CELE_R11A8.5
    See related
    AllianceGenome:WB:WBGene00011239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable prostaglandin-E synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in ganglia; germ line; hypodermis; intestinal cell; and muscle cell. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pges-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10366333..10367790, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G-patch domain and KOW motifs-containing protein homolog 1 Neighboring gene glucuronosyltransferase Neighboring gene Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 Neighboring gene Isoleucine--tRNA ligase, cytoplasmic Neighboring gene PDZ domain-containing protein Neighboring gene Ankyrin repeat and KH domain-containing protein mask-1;K Homology domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field. Sun Y, et al. Int J Radiat Biol, 2018 Dec. PMID 30307357
    2. The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction. Bamps S, et al. Mech Ageing Dev, 2009 Nov-Dec. PMID 19896965
    3. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Prostaglandin E synthase 2
    NP_501913.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10366333..10367790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069512.8 → NP_501913.1  Prostaglandin E synthase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21925
      Conserved Domains (3) summary
      cd03197
      Location:183 → 334
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
      COG0625
      Location:66 → 331
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:65 → 138
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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