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    fln-2 Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181168, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fln-2
    Official Full Name
    Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
    Primary source
    WormBase:WBGene00016006
    Locus tag
    CELE_C23F12.1
    See related
    AllianceGenome:WB:WBGene00016006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in organelle. Is expressed in several structures, including anal depressor muscle; distal tip cell; excretory canal; hypodermis; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See fln-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    53
    Sequence:
    Chromosome: X; NC_003284.9 (9397701..9427247)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc finger, CCHC-type Neighboring gene Transposase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase B0272.3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. DeMaso CR, et al. PLoS One, 2011. PMID 21799850, Free PMC Article
    2. FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans. Ma L, et al. Genetics, 2024 Jul 8. PMID 38797871,
    3. Intracellular Ca(2+) dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans. Miyazaki S, et al. iScience, 2022 Jun 17. PMID 35707721, Free PMC Article
    4. A fln-2 mutation affects lethal pathology and lifespan in C. elegans. Zhao Y, et al. Nat Commun, 2019 Nov 8. PMID 31704915, Free PMC Article
    5. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. Shi L, et al. J Cell Biol, 2022 Jul 4. PMID 35575797, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans.
      Title: FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans.
    2. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.
      Title: Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.
    3. gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2
      Title: Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.
    4. A nonsense mutation in fln-2 in the male stock reduces early mortality caused by pharyngeal infection. fln-2 variation confounds effects on lifespan of sir-2.1, daf-2, daf-12, and eat-2.
      Title: A fln-2 mutation affects lethal pathology and lifespan in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
    NP_001257074.2
    • Confirmed by transcript evidence
    NP_001257075.2
    • Confirmed by transcript evidence
    NP_001300321.1
    • Confirmed by transcript evidence
    NP_001300323.1
    • Confirmed by transcript evidence
    NP_001300324.1
    • Confirmed by transcript evidence
    NP_001300325.1
    • Confirmed by transcript evidence
    NP_001300326.1
    • Confirmed by transcript evidence
    NP_001300327.1
    • Confirmed by transcript evidence
    NP_001300328.1
    • Confirmed by transcript evidence
    NP_001300329.1
    • Confirmed by transcript evidence
    NP_001300330.1
    • Confirmed by transcript evidence
    NP_001300331.1
    • Confirmed by transcript evidence
    NP_001300332.1
    • Confirmed by transcript evidence
    NP_001359882.1
    • Confirmed by transcript evidence
    NP_001360405.1
    • Confirmed by transcript evidence
    NP_001360663.1
    • Confirmed by transcript evidence
    NP_001360664.1
    • Confirmed by transcript evidence
    NP_001360665.1
    • Confirmed by transcript evidence
    NP_001360666.1
    • Confirmed by transcript evidence
    NP_001360667.1
    • Confirmed by transcript evidence
    NP_001360668.1
    • Confirmed by transcript evidence
    NP_001368576.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9397701..9427247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373422.1 → NP_001359882.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL6
      Conserved Domains (6) summary
      PTZ00121
      Location:1506 → 1928
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3445 → 3539
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2933 → 3019
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:2589 → 2652
      Filamin; Filamin/ABP280 repeat

    2. NM_001373425.2 → NP_001360405.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT74
      Conserved Domains (5) summary
      PTZ00121
      Location:1475 → 1897
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3060 → 3154
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2548 → 2634
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    3. NM_001373423.2 → NP_001360663.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK09
      Conserved Domains (5) summary
      PTZ00121
      Location:1506 → 1928
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3091 → 3185
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2579 → 2665
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    4. NM_001373424.2 → NP_001360664.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKI4
      Conserved Domains (6) summary
      PTZ00121
      Location:1475 → 1897
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3414 → 3508
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2902 → 2988
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:2558 → 2621
      Filamin; Filamin/ABP280 repeat

    5. NM_001373426.2 → NP_001360665.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INA2
      Conserved Domains (6) summary
      PTZ00121
      Location:1478 → 1900
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3417 → 3511
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2905 → 2991
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762 → 826
      Filamin; Filamin/ABP280 repeat

    6. NM_001373427.2 → NP_001360666.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IN32
      Conserved Domains (6) summary
      PTZ00121
      Location:1478 → 1900
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3063 → 3157
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2551 → 2637
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762 → 826
      Filamin; Filamin/ABP280 repeat

    7. NM_001373428.2 → NP_001360667.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3C1
      Conserved Domains (6) summary
      PTZ00121
      Location:1447 → 1869
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3386 → 3480
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2874 → 2960
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762 → 826
      Filamin; Filamin/ABP280 repeat

    8. NM_001373429.2 → NP_001360668.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK63
      Conserved Domains (6) summary
      PTZ00121
      Location:1447 → 1869
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:3032 → 3126
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:2520 → 2606
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235 → 327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762 → 826
      Filamin; Filamin/ABP280 repeat

    9. NM_001381052.2 → NP_001368576.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASM8
      Conserved Domains (3) summary
      PTZ00121
      Location:138 → 560
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:1723 → 1817
      IG_FLMN; Filamin-type immunoglobulin domains
      cl27659
      Location:1231 → 1304
      Filamin; Filamin/ABP280 repeat

    10. NM_001313394.3 → NP_001300323.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW96
      Conserved Domains (3) summary
      smart00557
      Location:2873 → 2967
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2870 → 2960
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:689 → 879
      DUF4584; Domain of unknown function (DUF4584)

    11. NM_001313395.3 → NP_001300324.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYH6
      Conserved Domains (2) summary
      smart00557
      Location:2488 → 2582
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2485 → 2575
      Filamin; Filamin/ABP280 repeat

    12. NM_001313396.3 → NP_001300325.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT80
      Conserved Domains (3) summary
      smart00557
      Location:2698 → 2792
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2695 → 2785
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:514 → 704
      DUF4584; Domain of unknown function (DUF4584)

    13. NM_001313397.3 → NP_001300326.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVH8
      Conserved Domains (2) summary
      smart00557
      Location:2313 → 2407
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2310 → 2400
      Filamin; Filamin/ABP280 repeat

    14. NM_001270146.3 → NP_001257075.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL8
      Conserved Domains (2) summary
      smart00557
      Location:2225 → 2319
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2222 → 2312
      Filamin; Filamin/ABP280 repeat

    15. NM_001270145.4 → NP_001257074.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL7
      Conserved Domains (3) summary
      smart00557
      Location:2610 → 2704
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2607 → 2697
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:426 → 616
      DUF4584; Domain of unknown function (DUF4584)

    16. NM_001313398.3 → NP_001300327.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASN4
      Conserved Domains (3) summary
      smart00557
      Location:2554 → 2648
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2551 → 2641
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:370 → 560
      DUF4584; Domain of unknown function (DUF4584)

    17. NM_001313399.3 → NP_001300328.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWA2
      Conserved Domains (2) summary
      smart00557
      Location:2169 → 2263
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2166 → 2256
      Filamin; Filamin/ABP280 repeat

    18. NM_001313400.3 → NP_001300329.1  Filamin-A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYI1
      Conserved Domains (3) summary
      smart00557
      Location:2490 → 2584
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2487 → 2577
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:306 → 496
      DUF4584; Domain of unknown function (DUF4584)

    19. NM_001313401.3 → NP_001300330.1  Filamin-A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT86
      Conserved Domains (2) summary
      smart00557
      Location:2105 → 2199
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2102 → 2192
      Filamin; Filamin/ABP280 repeat

    20. NM_001313402.3 → NP_001300331.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVI4
      Conserved Domains (3) summary
      smart00557
      Location:2249 → 2343
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2246 → 2336
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:65 → 255
      DUF4584; Domain of unknown function (DUF4584)

    21. NM_001313403.3 → NP_001300332.1  ZM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASN9
      Conserved Domains (2) summary
      smart00557
      Location:1864 → 1958
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:1861 → 1951
      Filamin; Filamin/ABP280 repeat

    22. NM_001313392.3 → NP_001300321.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVH5
      Conserved Domains (2) summary
      smart00557
      Location:2077 → 2171
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2074 → 2164
      Filamin; Filamin/ABP280 repeat

    RNA

    1. NR_132548.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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