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    LILRB4 leukocyte immunoglobulin like receptor B4 [ Homo sapiens (human) ]

    Gene ID: 11006, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LILRB4provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor B4provided by HGNC
    Primary source
    HGNC:HGNC:6608
    See related
    Ensembl:ENSG00000186818 MIM:604821; AllianceGenome:HGNC:6608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B4; ILT3; LIR5; CD85K; ILT-3; LIR-5
    Summary
    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 9.2), lymph node (RPKM 8.1) and 17 other tissues See more
    Orthologs
    all
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    Genomic context

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    See LILRB4 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54662985..54668718)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57737351..57762244)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55174437..55180169)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 8061 Neighboring gene vomeronasal 1 receptor 105 pseudogene Neighboring gene MPRA-validated peak3558 silencer Neighboring gene leukocyte immunoglobulin-like receptor pseudogene 1 Neighboring gene leukocyte immunoglobulin-like receptor pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b. Jensen MA, et al. Mult Scler, 2010 Jan. PMID 20007427
    2. A dual positive and negative regulation of monocyte activation by leukocyte Ig-like receptor B4 depends on the position of the tyrosine residues in its ITIMs. Park M, et al. Innate Immun, 2017 May. PMID 28409541
    3. Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE. Inui M, et al. Int Immunol, 2016 Dec. PMID 27742834
    4. Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells. Dokić J, et al. Eur J Immunol, 2013 Jul. PMID 23616249
    5. Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. Heinzmann A, et al. Eur J Immunogenet, 2000 Jun. PMID 10940079

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway.
      Title: LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway.
    2. LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-kappaB/RELT signal pathway.
      Title: LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway.
    3. Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection.
      Title: Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection.
    4. LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets.
      Title: LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets.
    5. LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
      Title: LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
    6. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.
      Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.
    7. Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation.
      Title: Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation.
    8. ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.
      Title: ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.
    9. Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation.
      Title: Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation.
    10. LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy.
      Title: LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables apolipoprotein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc receptor mediated inhibitory signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of IP-10 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell costimulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytotoxic T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-5 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of monocyte activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of monocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tolerance induction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily B member 4
    Names
    CD85 antigen-like family member K
    immunoglobulin-like transcript 3
    leucocyte Ig-like receptor B4
    leukocyte immunoglobulin-like receptor 5
    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
    monocyte inhibitory receptor HM18

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278426.4 → NP_001265355.2  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001265355.2

      Status: REVIEWED

      Source sequence(s)
      AC243962
      Consensus CDS
      CCDS12902.1
      UniProtKB/TrEMBL
      A0A0G2JP25, A0A0G2JQ10, A0A8Q3SHR1
      Related
      ENSP00000511897.1, ENST00000695418.1
      Conserved Domains (3) summary
      cd05751
      Location:27 → 118
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:130 → 198
      IG_like; Immunoglobulin like
      cl11960
      Location:123 → 217
      Ig; Immunoglobulin domain

    2. NM_001278427.4 → NP_001265356.2  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      Consensus CDS
      CCDS42618.1
      UniProtKB/TrEMBL
      A0A0A0MSZ8, A0A0G2JP84, A0A0G2JPC7
      Related
      ENSP00000408995.2, ENST00000430952.6
      Conserved Domains (3) summary
      cd05751
      Location:27 → 118
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:130 → 198
      IG_like; Immunoglobulin like
      cl11960
      Location:123 → 217
      Ig; Immunoglobulin domain

    3. NM_001278428.4 → NP_001265357.2  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JNE9, A0A0G2JQ20
      Conserved Domains (3) summary
      cd05751
      Location:27 → 118
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:130 → 198
      IG_like; Immunoglobulin like
      cl11960
      Location:123 → 217
      Ig; Immunoglobulin domain

    4. NM_001278429.4 → NP_001265358.3  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JM38

    5. NM_001278430.4 → NP_001265359.2  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/Swiss-Prot
      Q8NHJ6
      Conserved Domains (3) summary
      cd05751
      Location:27 → 118
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:130 → 198
      IG_like; Immunoglobulin like
      cl11960
      Location:123 → 217
      Ig; Immunoglobulin domain

    6. NM_001394933.1 → NP_001381862.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      Consensus CDS
      CCDS92687.1
      UniProtKB/TrEMBL
      A0A0A0MS20, A0A0G2JMH7, A0A0G2JPX5
      Related
      ENSP00000375613.3, ENST00000391733.7

    7. NM_001394934.1 → NP_001381863.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JP25, A0A0G2JQ10
      Related
      ENSP00000401962.1, ENST00000434286.1

    8. NM_001394935.1 → NP_001381864.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JP84, A0A0G2JPC7

    9. NM_001394936.1 → NP_001381865.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JM38

    10. NM_001394937.1 → NP_001381866.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JM38

    11. NM_001394938.1 → NP_001381867.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      UniProtKB/TrEMBL
      A0A0G2JM38

    12. NM_001394939.1 → NP_001381868.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC243962
      Consensus CDS
      CCDS92688.1
      UniProtKB/TrEMBL
      A0A0G2JPA9, A8MUE1
      Related
      ENSP00000375614.3, ENST00000391734.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54662985..54668718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026216.2 → XP_016881705.2  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMH7, A0A0G2JPX5

    2. XM_047438100.1 → XP_047294056.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JM38

    3. XM_047438101.1 → XP_047294057.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JM38

    4. XM_047438103.1 → XP_047294059.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JM38

    5. XM_047438102.1 → XP_047294058.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JPA9

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      550227..575121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329637.1 → XP_054185612.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JMH7

    2. XM_054329633.1 → XP_054185608.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JMH7

    3. XM_054329636.1 → XP_054185611.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JNE9

    4. XM_054329635.1 → XP_054185610.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JQ10

    5. XM_054329638.1 → XP_054185613.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JPC7

    6. XM_054329639.1 → XP_054185614.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JQ10

    7. XM_054329640.1 → XP_054185615.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JPC7

    8. XM_054329641.1 → XP_054185616.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JM38

    9. XM_054329642.1 → XP_054185617.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JM38

    10. XM_054329643.1 → XP_054185618.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JM38

    11. XM_054329644.1 → XP_054185619.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JM38

    12. XM_054329645.1 → XP_054185620.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JM38

    13. XM_054329634.1 → XP_054185609.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JMH7

    14. XM_054329646.1 → XP_054185621.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JM38

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      548719..573600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331473.1 → XP_054187448.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JPA9

    2. XM_054331463.1 → XP_054187438.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JPX5

    3. XM_054331465.1 → XP_054187440.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X20

      UniProtKB/TrEMBL
      A0A0G2JQ20

    4. XM_054331464.1 → XP_054187439.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X19

      UniProtKB/TrEMBL
      A0A0G2JP25

    5. XM_054331466.1 → XP_054187441.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X21

      UniProtKB/TrEMBL
      A0A0G2JPX5

    6. XM_054331468.1 → XP_054187443.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X23

      UniProtKB/TrEMBL
      A0A0G2JP25

    7. XM_054331469.1 → XP_054187444.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X24

      UniProtKB/TrEMBL
      A0A0G2JP84

    8. XM_054331470.1 → XP_054187445.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X25

      UniProtKB/TrEMBL
      A0A0G2JM38

    9. XM_054331472.1 → XP_054187447.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X27

      UniProtKB/TrEMBL
      A0A0G2JM38

    10. XM_054331467.1 → XP_054187442.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JP84

    11. XM_054331471.1 → XP_054187446.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X26

      UniProtKB/TrEMBL
      A0A0G2JM38

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      370326..395222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333512.1 → XP_054189487.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X29

      UniProtKB/TrEMBL
      A0A0G2JPU4

    2. XM_054333515.1 → XP_054189490.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X31

      UniProtKB/TrEMBL
      A0A0G2JM84

    3. XM_054333514.1 → XP_054189489.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X30

      UniProtKB/TrEMBL
      A0A0G2JML1

    4. XM_054333517.1 → XP_054189492.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X33

      UniProtKB/TrEMBL
      A0A0G2JM57

    5. XM_054333516.1 → XP_054189491.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X32

      UniProtKB/TrEMBL
      A0A0G2JPU4

    6. XM_054333518.1 → XP_054189493.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X34

      UniProtKB/TrEMBL
      A0A0G2JML1

    7. XM_054333519.1 → XP_054189494.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X35

      UniProtKB/TrEMBL
      A0A0G2JM57

    8. XM_054333520.1 → XP_054189495.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X36

      UniProtKB/TrEMBL
      A0A0G2JM38

    9. XM_054333521.1 → XP_054189496.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X37

      UniProtKB/TrEMBL
      A0A0G2JM38

    10. XM_054333522.1 → XP_054189497.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X38

      UniProtKB/TrEMBL
      A0A0G2JM38

    11. XM_054333513.1 → XP_054189488.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X29

      UniProtKB/TrEMBL
      A0A0G2JPU4

    12. XM_054333523.1 → XP_054189498.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JM38

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      626406..651283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333608.1 → XP_054189583.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X51

      UniProtKB/TrEMBL
      A0A0G2JPA9

    2. XM_054333595.1 → XP_054189570.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X39

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5
      UniProtKB/TrEMBL
      A0A0G2JPU4

    3. XM_054333598.1 → XP_054189573.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X41

      UniProtKB/TrEMBL
      A0A0G2JM84

    4. XM_054333597.1 → XP_054189572.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X40

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5

    5. XM_054333600.1 → XP_054189575.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X43

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5

    6. XM_054333599.1 → XP_054189574.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X42

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5
      UniProtKB/TrEMBL
      A0A0G2JPU4

    7. XM_054333602.1 → XP_054189577.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X45

      UniProtKB/TrEMBL
      A0A0G2JM84

    8. XM_054333601.1 → XP_054189576.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X44

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5

    9. XM_054333603.1 → XP_054189578.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X46

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5

    10. XM_054333604.1 → XP_054189579.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X47

      UniProtKB/TrEMBL
      A0A0G2JM38, A0A0G2JNL1

    11. XM_054333605.1 → XP_054189580.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X48

      UniProtKB/TrEMBL
      A0A0G2JM38

    12. XM_054333606.1 → XP_054189581.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X49

      UniProtKB/TrEMBL
      A0A0G2JM38

    13. XM_054333607.1 → XP_054189582.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X50

      UniProtKB/TrEMBL
      A0A0G2JM38

    14. XM_054333596.1 → XP_054189571.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X39

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5
      UniProtKB/TrEMBL
      A0A0G2JPU4

    15. XM_054333609.1 → XP_054189584.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JM38

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57737351..57762244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319640.1 → XP_054175615.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X65

      UniProtKB/TrEMBL
      A0A0G2JPA9

    2. XM_054319627.1 → XP_054175602.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X52

      UniProtKB/TrEMBL
      A0A0G2JPU4

    3. XM_054319629.1 → XP_054175604.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X54

      UniProtKB/TrEMBL
      A0A0G2JM84

    4. XM_054319630.1 → XP_054175605.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X55

      UniProtKB/TrEMBL
      A0A0G2JPU4

    5. XM_054319633.1 → XP_054175608.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X58

      UniProtKB/TrEMBL
      A0A0G2JM84

    6. XM_054319632.1 → XP_054175607.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X57

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5
      UniProtKB/TrEMBL
      A0A0G2JML1

    7. XM_054319634.1 → XP_054175609.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X59

      UniProtKB/TrEMBL
      A0A0G2JM57

    8. XM_054319635.1 → XP_054175610.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X60

      UniProtKB/TrEMBL
      A0A0G2JM38

    9. XM_054319636.1 → XP_054175611.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X61

      UniProtKB/TrEMBL
      A0A0G2JM38

    10. XM_054319637.1 → XP_054175612.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X62

      UniProtKB/TrEMBL
      A0A0G2JM38

    11. XM_054319638.1 → XP_054175613.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X63

      UniProtKB/TrEMBL
      A0A0G2JM38

    12. XM_054319639.1 → XP_054175614.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X64

      UniProtKB/TrEMBL
      A0A0G2JM38

    13. XM_054319628.1 → XP_054175603.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X53

      UniProtKB/Swiss-Prot
      A8MVL8, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHJ6, Q8NHL5
      UniProtKB/TrEMBL
      A0A0G2JML1

    14. XM_054319631.1 → XP_054175606.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X56

      UniProtKB/TrEMBL
      A0A0G2JM57

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081438.1: Suppressed sequence

      Description
      NM_001081438.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_006847.3: Suppressed sequence

      Description
      NM_006847.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHJ6.3 GenPept UniProtKB/Swiss-Prot:Q8NHJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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