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    GOLGA1 golgin A1 [ Homo sapiens (human) ]

    Gene ID: 2800, updated on 27-Nov-2024

    Summary

    Official Symbol
    GOLGA1provided by HGNC
    Official Full Name
    golgin A1provided by HGNC
    Primary source
    HGNC:HGNC:4424
    See related
    Ensembl:ENSG00000136935 MIM:602502; AllianceGenome:HGNC:4424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    golgin-97
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GOLGA1 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124878275..124948043, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137076588..137151003, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127640554..127703362, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127620824-127621106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127621747-127622248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127622249-127622748 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene suppressor of cancer cell invasion Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with golgin A1 (GOLGA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33154

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    golgin subfamily A member 1
    Names
    gap junction protein, alpha 4, 37kD
    golgi autoantigen, golgin subfamily a, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002077.4NP_002068.2  golgin subfamily A member 1

      Status: REVIEWED

      Source sequence(s)
      AL354928, AL451125
      Consensus CDS
      CCDS6860.1
      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Related
      ENSP00000362656.4, ENST00000373555.9
      Conserved Domains (3) summary
      smart00755
      Location:692737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124878275..124948043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423242.1XP_047279198.1  golgin subfamily A member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
    2. XM_006717063.5XP_006717126.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006717126.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. XM_005251929.5XP_005251986.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_005251986.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    4. XM_006717062.5XP_006717125.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006717125.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_047423241.1XP_047279197.1  golgin subfamily A member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805

    RNA

    1. XR_929766.2 RNA Sequence

      Related
      ENST00000475407.5
    2. XR_007061280.1 RNA Sequence

    3. XR_007061279.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137076588..137151003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362760.1XP_054218735.1  golgin subfamily A member 1 isoform X1

    2. XM_054362757.1XP_054218732.1  golgin subfamily A member 1 isoform X1

    3. XM_054362758.1XP_054218733.1  golgin subfamily A member 1 isoform X1

    4. XM_054362761.1XP_054218736.1  golgin subfamily A member 1 isoform X1

    5. XM_054362759.1XP_054218734.1  golgin subfamily A member 1 isoform X1

    RNA

    1. XR_008487981.1 RNA Sequence

    2. XR_008487982.1 RNA Sequence

    3. XR_008487983.1 RNA Sequence