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    Slc37a2 solute carrier family 37 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc37a2provided by RGD
    Official Full Name
    solute carrier family 37 member 2provided by RGD
    Primary source
    RGD:1564160
    See related
    EnsemblRapid:ENSRNOG00000039390 AllianceGenome:RGD:1564160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564160
    Summary
    Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 35.3), Spleen (RPKM 29.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc37a2 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45134596..45160551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36945787..36971748, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39708678..39735042, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene PBX/knotted 1 homeobox 2 Neighboring gene uncharacterized LOC108351675 Neighboring gene transmembrane protein 218 Neighboring gene transfer RNA proline (anticodon AGG) 64 Neighboring gene coiled-coil domain containing 15 Neighboring gene uncharacterized LOC120094115 Neighboring gene hepatic and glial cell adhesion molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A2
    Names
    solute carrier family 37 (glucose-6-phosphate transporter), member 2
    solute carrier family 37 (glycerol-3-phosphate transporter), member 2
    sugar phosphate exchanger 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191994.2 → NP_001178923.1  glucose-6-phosphate exchanger SLC37A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A096MJU4, A0A8I6AHQ7
      Related
      ENSRNOP00000107303.1, ENSRNOT00000126302.1
      Conserved Domains (2) summary
      cd06174
      Location:86 → 481
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:77 → 463
      2A0104; phosphoglycerate transporter family protein

    2. NM_001412516.1 → NP_001399445.1  glucose-6-phosphate exchanger SLC37A2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AHQ7
      Related
      ENSRNOP00000068265.3, ENSRNOT00000076872.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45134596..45160551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081929.2 → XP_038937857.1  glucose-6-phosphate exchanger SLC37A2 isoform X1

      UniProtKB/TrEMBL
      A6KRM0
      Conserved Domains (1) summary
      cd17344
      Location:14 → 476
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version

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