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    NEK10 NIMA related kinase 10 [ Homo sapiens (human) ]

    Gene ID: 152110, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NEK10provided by HGNC
    Official Full Name
    NIMA related kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:18592
    See related
    Ensembl:ENSG00000163491 MIM:618726; AllianceGenome:HGNC:18592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CILD44
    Summary
    Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See NEK10 in Genome Data Viewer
    Location:
    3p24.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (27106484..27369383, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (27108644..27371532, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (27147975..27410874, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:26663597-26664112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:26665705-26666674 Neighboring gene LRRC3B antisense RNA 1 Neighboring gene uncharacterized LOC124909488 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:26727688-26727896 Neighboring gene leucine rich repeat containing 3B Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:26824284-26824877 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:26824878-26825470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19615 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:27083978-27084542 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:27085107-27085671 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:27084543-27085106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:27141697-27142896 Neighboring gene NANOG hESC enhancer GRCh37_chr3:27147157-27147736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14148 Neighboring gene MPRA-validated peak4579 silencer Neighboring gene MICOS10 pseudogene 3 Neighboring gene RNA, U6 small nuclear 342, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:27352339-27353538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27410132-27410632 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27483819-27484320 Neighboring gene solute carrier family 4 member 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27505552-27506411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27513115-27513615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27525149-27525925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19619 Neighboring gene ribosomal protein S20 pseudogene 15 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report. Al Mutairi F, et al. BMC Pulm Med, 2020 May 15. PMID 32414360, Free PMC Article
    2. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Chivukula RR, et al. Nat Med, 2020 Feb. PMID 31959991, Free PMC Article
    3. β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells. Dutt P, et al. Proc Natl Acad Sci U S A, 2024 May 7. PMID 38683979, Free PMC Article
    4. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Haider N, et al. Oncogene, 2020 Jul. PMID 32561851
    5. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Ahmed S, et al. Nat Genet, 2009 May. PMID 19330027, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
      Title: β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
    2. Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.
      Title: Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.
    3. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.
      Title: NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.
    4. analysis of a bronchiectasis syndrome caused by mutations that inactivate NIMA-related kinase 10 (NEK10), a protein kinase with previously unknown in vivo functions in mammals
      Title: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
    5. Nek10 physically associated with Raf-1 and MEK1 in a Raf-1-dependent manner, and the formation of this complex was necessary for Nek10-mediated MEK1 activation.
      Title: Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Common genetic variants associated with breast cancer and mammographic density measures that predict disease.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Ciliary dyskinesia, primary, 44
    MedGen: C5394063 OMIM: 618781 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32685

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mucociliary clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle G2/M phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek10
    Names
    NIMA (never in mitosis gene a)- related kinase 10
    never in mitosis A-related kinase 10
    nimA-related protein kinase 10
    NP_001026911.1
    NP_001291313.1
    NP_001381892.1
    NP_001381893.1
    NP_001381894.1
    NP_001381895.1
    NP_001381896.1
    NP_001381897.1
    NP_001381898.1
    NP_001381899.1
    NP_001381900.1
    NP_689747.3
    NP_955379.2
    XP_006713061.1
    XP_006713062.1
    XP_006713064.1
    XP_011531716.1
    XP_016861251.1
    XP_016861252.1
    XP_016861253.1
    XP_016861254.1
    XP_016861257.1
    XP_016861263.1
    XP_047303461.1
    XP_047303462.1
    XP_047303463.1
    XP_047303464.1
    XP_047303465.1
    XP_047303466.1
    XP_047303467.1
    XP_047303468.1
    XP_054201339.1
    XP_054201340.1
    XP_054201341.1
    XP_054201342.1
    XP_054201343.1
    XP_054201344.1
    XP_054201345.1
    XP_054201346.1
    XP_054201347.1
    XP_054201348.1
    XP_054201349.1
    XP_054201350.1
    XP_054201351.1
    XP_054201352.1
    XP_054201353.1
    XP_054201354.1
    XP_054201355.1
    XP_054201356.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031741.5 → NP_001026911.1  serine/threonine-protein kinase Nek10 isoform 1

      See identical proteins and their annotated locations for NP_001026911.1

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931
      Related
      ENSP00000373281.4, ENST00000383771.8
      Conserved Domains (1) summary
      cl21453
      Location:10 → 97
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001304384.3 → NP_001291313.1  serine/threonine-protein kinase Nek10 isoform 4

      See identical proteins and their annotated locations for NP_001291313.1

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931
      Consensus CDS
      CCDS77713.1
      Related
      ENSP00000295720.6, ENST00000295720.10
      Conserved Domains (1) summary
      cl21453
      Location:10 → 97
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001394963.1 → NP_001381892.1  serine/threonine-protein kinase Nek10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    4. NM_001394964.1 → NP_001381893.1  serine/threonine-protein kinase Nek10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:489 → 756
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    5. NM_001394965.1 → NP_001381894.1  serine/threonine-protein kinase Nek10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2C8, A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    6. NM_001394966.1 → NP_001381895.1  serine/threonine-protein kinase Nek10 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      Consensus CDS
      CCDS93229.1
      UniProtKB/TrEMBL
      A0A650C2D3, A0A8I5KTB8
      Related
      ENSP00000509472.1, ENST00000691995.1
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    7. NM_001394967.1 → NP_001381896.1  serine/threonine-protein kinase Nek10 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:489 → 756
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    8. NM_001394968.1 → NP_001381897.1  serine/threonine-protein kinase Nek10 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cl21453
      Location:525 → 746
      PKc_like; Protein Kinases, catalytic domain

    9. NM_001394969.1 → NP_001381898.1  serine/threonine-protein kinase Nek10 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cl21453
      Location:489 → 689
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001394970.1 → NP_001381899.1  serine/threonine-protein kinase Nek10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Related
      ENSP00000395849.2, ENST00000429845.6
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    11. NM_001394971.1 → NP_001381900.1  serine/threonine-protein kinase Nek10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/TrEMBL
      A0A650C2C8, A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    12. NM_152534.6 → NP_689747.3  serine/threonine-protein kinase Nek10 isoform 2

      See identical proteins and their annotated locations for NP_689747.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the inferred longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC093555, AC098931, AC099535
      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    13. NM_199347.4 → NP_955379.2  serine/threonine-protein kinase Nek10 isoform 3

      See identical proteins and their annotated locations for NP_955379.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, compared to variant 2, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK098832, AK123061, BX537852
      Consensus CDS
      CCDS46781.1
      UniProtKB/Swiss-Prot
      Q6ZWH5
      UniProtKB/TrEMBL
      Q8N774
      Related
      ENSP00000343847.5, ENST00000341435.9
      Conserved Domains (2) summary
      smart00220
      Location:519 → 695
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:518 → 697
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      27106484..27369383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447506.1 → XP_047303462.1  serine/threonine-protein kinase Nek10 isoform X6

      UniProtKB/TrEMBL
      A0A650C2D3

    2. XM_047447508.1 → XP_047303464.1  serine/threonine-protein kinase Nek10 isoform X8

      UniProtKB/TrEMBL
      A0A650C2D3

    3. XM_017005763.2 → XP_016861252.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    4. XM_047447507.1 → XP_047303463.1  serine/threonine-protein kinase Nek10 isoform X7

      UniProtKB/TrEMBL
      A0A650C2D3

    5. XM_017005768.2 → XP_016861257.1  serine/threonine-protein kinase Nek10 isoform X4

      UniProtKB/TrEMBL
      A0A650C2D3

    6. XM_006713001.4 → XP_006713064.1  serine/threonine-protein kinase Nek10 isoform X5

      UniProtKB/TrEMBL
      A0A650C2D3, A0A8I5KTB8
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    7. XM_047447505.1 → XP_047303461.1  serine/threonine-protein kinase Nek10 isoform X5

      UniProtKB/TrEMBL
      A0A650C2D3, A0A8I5KTB8

    8. XM_017005762.3 → XP_016861251.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    9. XM_017005764.2 → XP_016861253.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    10. XM_017005765.2 → XP_016861254.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    11. XM_006712999.4 → XP_006713062.1  serine/threonine-protein kinase Nek10 isoform X3

      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (2) summary
      smart00220
      Location:519 → 779
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    12. XM_006712998.3 → XP_006713061.1  serine/threonine-protein kinase Nek10 isoform X2

      UniProtKB/TrEMBL
      A0A650C2D3
      Conserved Domains (2) summary
      smart00220
      Location:519 → 779
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    13. XM_047447509.1 → XP_047303465.1  serine/threonine-protein kinase Nek10 isoform X9

      UniProtKB/TrEMBL
      A0A650C2D3

    14. XM_011533414.3 → XP_011531716.1  serine/threonine-protein kinase Nek10 isoform X12

      Conserved Domains (2) summary
      smart00220
      Location:519 → 669
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:518 → 672
      PKc_like; Protein Kinases, catalytic domain

    15. XM_047447512.1 → XP_047303468.1  serine/threonine-protein kinase Nek10 isoform X14

    16. XM_047447511.1 → XP_047303467.1  serine/threonine-protein kinase Nek10 isoform X13

    17. XM_047447510.1 → XP_047303466.1  serine/threonine-protein kinase Nek10 isoform X11

    18. XM_017005774.3 → XP_016861263.1  serine/threonine-protein kinase Nek10 isoform X10

      Conserved Domains (2) summary
      smart00220
      Location:519 → 669
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:518 → 672
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001740034.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      27108644..27371532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345373.1 → XP_054201348.1  serine/threonine-protein kinase Nek10 isoform X6

      UniProtKB/TrEMBL
      A0A650C2D3

    2. XM_054345375.1 → XP_054201350.1  serine/threonine-protein kinase Nek10 isoform X8

      UniProtKB/TrEMBL
      A0A650C2D3

    3. XM_054345364.1 → XP_054201339.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3

    4. XM_054345374.1 → XP_054201349.1  serine/threonine-protein kinase Nek10 isoform X7

      UniProtKB/TrEMBL
      A0A650C2D3

    5. XM_054345370.1 → XP_054201345.1  serine/threonine-protein kinase Nek10 isoform X4

      UniProtKB/TrEMBL
      A0A650C2D3

    6. XM_054345372.1 → XP_054201347.1  serine/threonine-protein kinase Nek10 isoform X5

      UniProtKB/TrEMBL
      A0A650C2D3, A0A8I5KTB8

    7. XM_054345371.1 → XP_054201346.1  serine/threonine-protein kinase Nek10 isoform X5

      UniProtKB/TrEMBL
      A0A650C2D3, A0A8I5KTB8

    8. XM_054345366.1 → XP_054201341.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3

    9. XM_054345367.1 → XP_054201342.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3

    10. XM_054345365.1 → XP_054201340.1  serine/threonine-protein kinase Nek10 isoform X1

      UniProtKB/Swiss-Prot
      A8MWG1, B9ZVR0, Q45VJ4, Q6ZR11, Q6ZWH5, Q7Z671, Q86XB1, Q96MB3
      UniProtKB/TrEMBL
      A0A650C2D3

    11. XM_054345369.1 → XP_054201344.1  serine/threonine-protein kinase Nek10 isoform X3

      UniProtKB/TrEMBL
      A0A650C2D3

    12. XM_054345368.1 → XP_054201343.1  serine/threonine-protein kinase Nek10 isoform X2

      UniProtKB/TrEMBL
      A0A650C2D3

    13. XM_054345376.1 → XP_054201351.1  serine/threonine-protein kinase Nek10 isoform X9

      UniProtKB/TrEMBL
      A0A650C2D3

    14. XM_054345379.1 → XP_054201354.1  serine/threonine-protein kinase Nek10 isoform X12

    15. XM_054345381.1 → XP_054201356.1  serine/threonine-protein kinase Nek10 isoform X14

    16. XM_054345380.1 → XP_054201355.1  serine/threonine-protein kinase Nek10 isoform X13

    17. XM_054345378.1 → XP_054201353.1  serine/threonine-protein kinase Nek10 isoform X11

    18. XM_054345377.1 → XP_054201352.1  serine/threonine-protein kinase Nek10 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWH5.3 GenPept UniProtKB/Swiss-Prot:Q6ZWH5

    Gene LinkOut

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