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    NOD1 nucleotide binding oligomerization domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 10392, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NOD1provided by HGNC
    Official Full Name
    nucleotide binding oligomerization domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:16390
    See related
    Ensembl:ENSG00000106100 MIM:605980; AllianceGenome:HGNC:16390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CARD4; NLRC1; hNod1; CLR7.1
    Summary
    This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOD1 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30424527..30478784, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30562221..30616484, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30464143..30518400, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:30430683-30431301 Neighboring gene long intergenic non-protein coding RNA 1176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25811 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30459231-30459834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30489142-30489642 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:30517896-30518640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30543653-30544532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30544533-30545411 Neighboring gene NANOG hESC enhancer GRCh37_chr7:30551764-30552265 Neighboring gene gamma-glutamylcyclotransferase Neighboring gene golgin A8 family member A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NOD1 modulates IL-10 signalling in human dendritic cells. Neuper T, et al. Sci Rep, 2017 Apr 21. PMID 28432285, Free PMC Article
    2. A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Zilbauer M, et al. Cell Microbiol, 2007 Oct. PMID 17521327
    3. Nucleotide-binding oligomerization domain 1 regulates Porphyromonas gingivalis-induced vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression in endothelial cells through NF-κB pathway. Wan M, et al. J Periodontal Res, 2015 Apr. PMID 24862550
    4. Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis. Kavathas PB, et al. Mucosal Immunol, 2013 Mar. PMID 22763410, Free PMC Article
    5. Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. Lassailly G, et al. J Hepatol, 2019 Jun. PMID 30685324

    See all (259) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.
      Title: The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.
    2. Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.
      Title: Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.
    3. NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-kB-independent manner.
      Title: NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner.
    4. Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.
      Title: Association between genetic polymorphisms of NOD1, Interleukin-1B, and cagA strain with low-grade duodenal eosinophilia in Helicobacter pylori-related dyspepsia.
    5. NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-kappaB.
      Title: NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-κB.
    6. Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.
      Title: Association of NOD1 and NOD2 Polymorphisms With Susceptibility to Subacute Sclerosing Panencephalitis.
    7. NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.
      Title: NOD1 activation in 3T3-L1 adipocytes confers lipid accumulation in HepG2 cells.
    8. Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.
      Title: Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.
    9. Activation of NOD1 and NOD2 in the development of liver injury and cancer.
      Title: Activation of NOD1 and NOD2 in the development of liver injury and cancer.
    10. Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Regulates Inflammatory Response in Endometriosis.
      Title: Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Regulates Inflammatory Response in Endometriosis.
    Submit: New GeneRIF Correction See all GeneRIFs (198)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CARD domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activator activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of biotic stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of xenophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleotide-binding oligomerization domain-containing protein 1
    Names
    NLR family, CARD domain containing 1
    caspase recruitment domain family, member 4
    caspase recruitment domain-containing protein 4
    nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013025.1 RefSeqGene

      Range
      4994..59251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001354849.2 → NP_001341778.1  nucleotide-binding oligomerization domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AA845215, AC005154, AC006027
      UniProtKB/TrEMBL
      B3KN80
      Conserved Domains (5) summary
      COG5635
      Location:170 → 542
      COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain
      cl26161
      Location:676 → 914
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_006092.4 → NP_006083.1  nucleotide-binding oligomerization domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006083.1

      Status: REVIEWED

      Source sequence(s)
      AA845215, AC005154, AF113925, BC040339, CV569884
      Consensus CDS
      CCDS5427.1
      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Related
      ENSP00000222823.4, ENST00000222823.9
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    RNA

    1. NR_149002.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA845215, AC005154, AF113925, AK023969

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      30424527..30478784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419760.1 → XP_047275716.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    2. XM_005249572.1 → XP_005249629.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005249629.1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    3. XM_047419763.1 → XP_047275719.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B3KN80

    4. XM_047419753.1 → XP_047275709.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80

    5. XM_047419765.1 → XP_047275721.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    6. XM_047419759.1 → XP_047275715.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    7. XM_047419768.1 → XP_047275724.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN80

    8. XM_047419762.1 → XP_047275718.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B3KN80

    9. XM_011515083.2 → XP_011513385.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 925
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    10. XM_011515085.2 → XP_011513387.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80
      Conserved Domains (4) summary
      cd00116
      Location:723 → 858
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 754
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    11. XM_011515084.2 → XP_011513386.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80
      Conserved Domains (5) summary
      COG5635
      Location:170 → 542
      COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain
      cl26161
      Location:676 → 914
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    12. XM_005249568.2 → XP_005249625.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005249625.1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    13. XM_047419761.1 → XP_047275717.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    14. XM_047419766.1 → XP_047275722.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    15. XM_047419755.1 → XP_047275711.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    16. XM_047419752.1 → XP_047275708.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    17. XM_047419758.1 → XP_047275714.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    18. XM_006715633.3 → XP_006715696.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715696.1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    19. XM_047419767.1 → XP_047275723.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    20. XM_047419756.1 → XP_047275712.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    21. XM_011515079.1 → XP_011513381.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513381.1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676 → 941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    22. XM_047419754.1 → XP_047275710.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80

    23. XM_047419757.1 → XP_047275713.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    24. XM_047419764.1 → XP_047275720.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X5

    25. XM_047419770.1 → XP_047275726.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X12

    26. XM_005249576.1 → XP_005249633.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X11

      Conserved Domains (3) summary
      cd00116
      Location:428 → 693
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:482 → 509
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:3 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    27. XM_011515087.2 → XP_011513389.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      B3KN80
      Conserved Domains (5) summary
      COG5635
      Location:89 → 542
      COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
      cd00116
      Location:723 → 821
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730 → 757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    28. XM_011515088.3 → XP_011513390.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X9

      See identical proteins and their annotated locations for XP_011513390.1

      UniProtKB/TrEMBL
      B3KN80, G3XAL1
      Related
      ENSP00000416946.1, ENST00000434755.5
      Conserved Domains (3) summary
      smart00382
      Location:194 → 291
      AAA; ATPases associated with a variety of cellular activities
      cd08324
      Location:21 → 105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      pfam05729
      Location:197 → 367
      NACHT; NACHT domain

    29. XM_047419769.1 → XP_047275725.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      B3KN80

    RNA

    1. XR_007059981.1 RNA Sequence

    2. XR_926910.2 RNA Sequence

    3. XR_001744530.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      30562221..30616484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357066.1 → XP_054213041.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    2. XM_054357056.1 → XP_054213031.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    3. XM_054357069.1 → XP_054213044.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B3KN80

    4. XM_054357058.1 → XP_054213033.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80

    5. XM_054357072.1 → XP_054213047.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    6. XM_054357065.1 → XP_054213040.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    7. XM_054357075.1 → XP_054213050.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN80

    8. XM_054357068.1 → XP_054213043.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B3KN80

    9. XM_054357057.1 → XP_054213032.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80

    10. XM_054357071.1 → XP_054213046.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    11. XM_054357060.1 → XP_054213035.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    12. XM_054357052.1 → XP_054213027.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    13. XM_054357067.1 → XP_054213042.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    14. XM_054357073.1 → XP_054213048.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    15. XM_054357061.1 → XP_054213036.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    16. XM_054357053.1 → XP_054213028.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    17. XM_054357064.1 → XP_054213039.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    18. XM_054357055.1 → XP_054213030.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    19. XM_054357074.1 → XP_054213049.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B3KN80

    20. XM_054357062.1 → XP_054213037.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    21. XM_054357054.1 → XP_054213029.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DTU3, Q549U4, Q8IWF5, Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73

    22. XM_054357059.1 → XP_054213034.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B3KN80

    23. XM_054357063.1 → XP_054213038.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B3KN80

    24. XM_054357070.1 → XP_054213045.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X5

    25. XM_054357080.1 → XP_054213055.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X12

    26. XM_054357079.1 → XP_054213054.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X11

    27. XM_054357076.1 → XP_054213051.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      B3KN80

    28. XM_054357077.1 → XP_054213052.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN80, G3XAL1

    29. XM_054357078.1 → XP_054213053.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      B3KN80

    RNA

    1. XR_008487520.1 RNA Sequence

    2. XR_008487521.1 RNA Sequence

    3. XR_008487523.1 RNA Sequence

    4. XR_008487522.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y239.1 GenPept UniProtKB/Swiss-Prot:Q9Y239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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