GET1 GET complex subunit GET1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GET1
Official Full Name: GET complex subunit GET1
Primary source: SGD:S000002988
Locus tag: YGL020C
See related: AllianceGenome:SGD:S000002988; FungiDB:YGL020C; VEuPathDB:YGL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MDM39
Summary: Enables protein transmembrane transporter activity and protein-membrane adaptor activity. Contributes to membrane insertase activity. Involved in establishment of protein localization to membrane; mitophagy; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum and mitochondrion. Part of GET complex. Is active in endoplasmic reticulum membrane. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GET1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (457163..457870, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER.
Title: The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER.
GET 1, 2, 3 proteins target MOM proteins to the endoplasmic reticulum.
Title: The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER.
Mitophagy during prolonged respiratory growth is strongly impaired in cells lacking Get1/2, a transmembrane complex mediating insertion of tail-anchored (TA) proteins into the endoplasmic reticulum (ER) membrane. Under the same conditions, loss of Get1/2 caused only slight defects in other types of selective and bulk autophagy.
Title: The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast.
The authors show that endoplasmic reticulum membrane proteins Get1p and Get2p are required for maintaining normal levels of cardiolipin.
Title: Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels.
identification of mutations in the Get1/2 transmembrane domain that disrupt tail-anchored protein insertion without interfering with Get1/2 cytosolic domain function
Title: The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.
Get1 uses two interfaces to stabilize the open dimer conformation of Get3.
Title: Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces.
crystal structures of Get3 in complex with cytosolic domain of Get1 and Get2 in different states; data show Get1 and Get2 can bind simultaneously to Get3;docking to Get1/2 complex allows for conformational change in Get3 required for TA protein insertion
Title: Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.
Mdm39p, which may be related to the regulation of calcium ion fluxes in the ER, and is indispensable for mutants that lack Spf1p.
Title: Cooperative function of the CHD5-like protein Mdm39p with a P-type ATPase Spf1p in the maintenance of ER homeostasis in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GET complex	IEA Inferred from Electronic Annotation more info
part_of GET complex	IPI Inferred from Physical Interaction more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GET complex subunit GET1

NP_011495.1

Subunit of the GET complex; involved in insertion of tail-anchored proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane