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    putative cystathionine beta-lyase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856512, updated on 9-Dec-2024

    Summary

    Official Full Name
    putative cystathionine beta-lyase
    Primary source
    SGD:S000001154
    Locus tag
    YHR112C
    See related
    AllianceGenome:SGD:S000001154; FungiDB:YHR112C; VEuPathDB:YHR112C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cysteine-S-conjugate beta-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in transsulfuration. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (334527..335663, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Erp5p Neighboring gene Uba4p Neighboring gene aspartyl aminopeptidase Neighboring gene Bzz1p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbon-sulfur lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-S-conjugate beta-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in sulfur compound metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative cystathionine beta-lyase
    NP_011980.1
    • hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      334527..335663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179242.1NP_011980.1  TPA: putative cystathionine beta-lyase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL62, P38716
      UniProtKB/TrEMBL
      A6ZT20, B3LSM7, C7GLZ8, C8Z9Q5, G2WFI6, N1P289
      Conserved Domains (1) summary
      cd00614
      Location:20372
      CGS_like; Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and ...