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    IRC25 Irc25p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IRC25
    Official Full Name
    Irc25p
    Primary source
    SGD:S000004011
    Locus tag
    YLR021W
    See related
    AllianceGenome:SGD:S000004011; FungiDB:YLR021W; VEuPathDB:YLR021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DMP2; PBA3; POC3
    Summary
    Involved in chaperone-mediated protein complex assembly; nuclear-transcribed mRNA catabolic process, non-stop decay; and proteasome assembly. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IRC25 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (183623..184162)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative phosphatase Neighboring gene sterol esterase Neighboring gene guanine nucleotide exchange factor SDO1 Neighboring gene Izh3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis. Jawed A, et al. Front Mol Biosci, 2022. PMID 36660429, Free PMC Article
    2. Blm10 binds to pre-activated proteasome core particles with open gate conformation. Lehmann A, et al. EMBO Rep, 2008 Dec. PMID 18927584, Free PMC Article
    3. Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast. Howell LA, et al. Sci Rep, 2019 Aug 27. PMID 31455793, Free PMC Article
    4. Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation. Takagi K, et al. Biochem Biophys Res Commun, 2014 Jul 25. PMID 24996173
    5. Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly. Matias AC, et al. Biomolecules, 2022 Dec 21. PMID 36671396, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Irc25p
    NP_013121.1
    • Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      183623..184162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181908.1 → NP_013121.1  TPA: Irc25p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013121.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY23, Q07951
      UniProtKB/TrEMBL
      A7A0S6, B3LSZ4, C7GXG7, C8ZCZ3, G2WIL5
      Conserved Domains (1) summary
      pfam10448
      Location:1 → 174
      POC3_POC4; 20S proteasome chaperone assembly proteins 3 and 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07951.1

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