Wdr62 WD repeat domain 62 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wdr62provided by FlyBase
Official Full Name: WD repeat domain 62provided by FlyBase
Primary source: FLYBASE:FBgn0031374
Locus tag: Dmel_CG7337
See related: AllianceGenome:FB:FBgn0031374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7337; Dmel\CG7337; Q0E8U7_DROME; wdr62; WDR62
Summary: Involved in regulation of mitotic cell cycle. Located in interphase microtubule organizing center and mitotic spindle. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic foregut; and epithelium. Used to study high grade glioma; microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Human ortholog(s) of this gene implicated in intellectual disability; nephronophthisis 20; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62) and MAPKBP1 (mitogen-activated protein kinase binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 22B4-22B6; 2-3 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1884622..1944289)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1884622..1944289)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Title: Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Me31B and Wdr62 function as two novel modulators of Notch signaling activity.
Title: A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
WDR62 controls brain growth through lineage-specific interactions with master mitotic signaling kinase, aurora A kinase.
Title: Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.
CG7337/Wdr62, a microtubule-associated protein, is required for the maintenance of interphase microtubules, thereby regulating centrosomal Polo and Plp levels.
Title: The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0162 (e-PCR)
- UniSTS:60706

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in interphase microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat domain 62

Names: CG7337-PA; CG7337-PB; CG7337-PC; CG7337-PD; CG7337-PE; CG7337-PF; CG7337-PG; CG7337-PH; Wdr62-PA; Wdr62-PB; Wdr62-PC; Wdr62-PD; Wdr62-PE; Wdr62-PF; Wdr62-PG; Wdr62-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1884622..1944289

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134786.6 → NP_608630.2 WD repeat domain 62, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608630.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VQ54

Related

FBpp0077488

Conserved Domains (3) summary

COG2319
Location:402 → 716

WD40; WD40 repeat [General function prediction only]

sd00039
Location:514 → 555

7WD40; WD40 repeat [structural motif]

cl02567
Location:405 → 717

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001103581.3 → NP_001097051.1 WD repeat domain 62, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097051.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VQ54

Conserved Domains (3) summary

COG2319
Location:402 → 716

WD40; WD40 repeat [General function prediction only]

sd00039
Location:514 → 555

7WD40; WD40 repeat [structural motif]

cl02567
Location:405 → 717

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001272958.1 → NP_001259887.1 WD repeat domain 62, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259887.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBP2

Conserved Domains (3) summary

COG2319
Location:402 → 716

WD40; WD40 repeat [General function prediction only]

sd00039
Location:514 → 555

7WD40; WD40 repeat [structural motif]

cl02567
Location:405 → 717

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001103580.2 → NP_001097050.1 WD repeat domain 62, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097050.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DYT1

Conserved Domains (3) summary

COG2319
Location:433 → 747

WD40; WD40 repeat [General function prediction only]

sd00039
Location:545 → 586

7WD40; WD40 repeat [structural motif]

cl02567
Location:436 → 748

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001272957.1 → NP_001259886.1 WD repeat domain 62, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259886.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PB01

Conserved Domains (3) summary

COG2319
Location:385 → 747

WD40; WD40 repeat [General function prediction only]

sd00039
Location:505 → 540

7WD40; WD40 repeat [structural motif]

cl02567
Location:436 → 748

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001258915.2 → NP_001245844.1 WD repeat domain 62, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245844.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE65

Conserved Domains (3) summary

COG2319
Location:433 → 747

WD40; WD40 repeat [General function prediction only]

sd00039
Location:545 → 586

7WD40; WD40 repeat [structural motif]

cl02567
Location:436 → 748

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001042862.2 → NP_001036327.1 WD repeat domain 62, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036327.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8U7

Conserved Domains (3) summary

COG2319
Location:350 → 712

WD40; WD40 repeat [General function prediction only]

sd00039
Location:470 → 505

7WD40; WD40 repeat [structural motif]

cl02567
Location:401 → 713

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001042863.2 → NP_001036328.1 WD repeat domain 62, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036328.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8U6

Conserved Domains (3) summary

COG2319
Location:398 → 712

WD40; WD40 repeat [General function prediction only]

sd00039
Location:510 → 551

7WD40; WD40 repeat [structural motif]

cl02567
Location:401 → 713

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...