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    Zif Zinc-finger protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zifprovided by FlyBase
    Official Full Name
    Zinc-finger proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037446
    Locus tag
    Dmel_CG10267
    See related
    AllianceGenome:FB:FBgn0037446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.391; CC32; CG10267; Dmel\CG10267; zif; ZIF
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in establishment or maintenance of neuroblast polarity; larval lymph gland hemopoiesis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; gonad; larval neurons; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zif in Genome Data Viewer
    Location:
    83E8-83E8; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6457088..6458822)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2282810..2284544)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44017 Neighboring gene grappa Neighboring gene mir-9375 stem loop Neighboring gene uncharacterized protein Neighboring gene neurochondrin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system. Burguete AS, et al. Dev Biol, 2019 Jul 1. PMID 30735663, Free PMC Article
    2. Transcriptional and epigenetic signatures of zygotic genome activation during early Drosophila embryogenesis. Darbo E, et al. BMC Genomics, 2013 Apr 5. PMID 23560912, Free PMC Article
    3. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
    4. Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal. Chang KC, et al. Dev Cell, 2010 Nov 16. PMID 21074726
    5. Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid. Li M, et al. PLoS One, 2023. PMID 36595500, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Zif is a transcription factor that directly represses aPKC transcription.
      Title: Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of neuroblast polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc-finger protein
    Names
    CG10267-PA
    CG10267-PB
    CG10267-PC
    Zif-PA
    Zif-PB
    Zif-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6457088..6458822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275390.1 → NP_001262319.1  Zinc-finger protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI24
      Conserved Domains (4) summary
      COG5048
      Location:250 → 369
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:9 → 87
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:266 → 288
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001202259.2 → NP_001189188.1  Zinc-finger protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI24
      Conserved Domains (4) summary
      COG5048
      Location:250 → 369
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:9 → 87
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:266 → 288
      zf-H2C2_2; Zinc-finger double domain

    3. NM_141400.4 → NP_649657.1  Zinc-finger protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI24
      Related
      FBpp0081225
      Conserved Domains (4) summary
      COG5048
      Location:250 → 369
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:9 → 87
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:266 → 288
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI24 Q9VI24

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