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    WASp WASp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43402, updated on 9-Dec-2024

    Summary

    Official Symbol
    WASpprovided by FlyBase
    Official Full Name
    WASpprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024273
    Locus tag
    Dmel_CG1520
    See related
    AllianceGenome:FB:FBgn0024273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1520; D-WASP; Dm WASP; Dmel\CG1520; DmWASP; dWASP; N-WASP; wasp; Wasp; WASP; wsp; Wsp; WSP
    Summary
    Predicted to enable small GTPase binding activity. Involved in several processes, including axon development; cytoskeleton organization; and epithelial cell differentiation. Located in several cellular components, including microvillus; neuromuscular junction; and rhabdomere. Part of protein-containing complex. Is expressed in several structures, including adult head; embryonic salivary gland duct; embryonic ventral epidermis; embryonic/larval neuromuscular junction; and epithelium. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to several human genes including WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WASp in Genome Data Viewer
    Location:
    98E5-98E5; 3-97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28824506..28832024, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24650228..24657746, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pre-mRNA processing factor 39 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene APC-like Neighboring gene sponge Neighboring gene Innexin 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric cell division TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonal fasciculation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell competition in a multicellular organism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate commitment TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle budding from membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in rhabdomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    WASp
    Names
    CG1520-PA
    CG1520-PB
    CG1520-PC
    CG1520-PD
    WASP
    WASp-PA
    WASp-PB
    WASp-PC
    WASp-PD
    Wiscott-Aldrich syndrome protein
    Wiskott-Aldrich syndrome protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28824506..28832024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143380.4NP_651637.1  WASp, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAT0
      Related
      FBpp0084721
      Conserved Domains (3) summary
      pfam00568
      Location:31140
      WH1; WH1 domain
      pfam00786
      Location:233291
      PBD; P21-Rho-binding domain
      pfam02205
      Location:433453
      WH2; WH2 motif
    2. NM_170378.2NP_733257.1  WASp, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAT0
      Related
      FBpp0084722, FBtr0085353
      Conserved Domains (3) summary
      pfam00568
      Location:31140
      WH1; WH1 domain
      pfam00786
      Location:233291
      PBD; P21-Rho-binding domain
      pfam02205
      Location:433453
      WH2; WH2 motif
    3. NM_001276116.1NP_001263045.1  WASp, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAT0
      Conserved Domains (3) summary
      pfam00568
      Location:31140
      WH1; WH1 domain
      pfam00786
      Location:233291
      PBD; P21-Rho-binding domain
      pfam02205
      Location:433453
      WH2; WH2 motif
    4. NM_176578.2NP_788755.1  WASp, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B74
      Related
      FBpp0084723
      Conserved Domains (3) summary
      pfam00568
      Location:3107
      WH1; WH1 domain
      pfam00786
      Location:200258
      PBD; P21-Rho-binding domain
      pfam02205
      Location:400420
      WH2; WH2 motif