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    Mrtf Myocardin-related transcription factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38338, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mrtfprovided by FlyBase
    Official Full Name
    Myocardin-related transcription factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052296
    Locus tag
    Dmel_CG32296
    See related
    AllianceGenome:FB:FBgn0052296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12188; CG14951; CG32296; Dmel\CG32296; dMrtf; dMRTF; DMRTF; mal; mal-d; Mal-D; MAL-D; MRTF
    Summary
    Enables DNA-binding transcription factor binding activity and transcription coactivator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including border follicle cell migration; cellular response to hypoxia; and mesodermal cell migration. Located in cytoplasm and nucleus. Is expressed in several structures, including border follicle cell; egg chamber; larval muscle cell; and ovary. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia; congenital megabladder; dilated cardiomyopathy; and immunodeficiency 66. Orthologous to human MYOCD (myocardin); MRTFA (myocardin related transcription factor A); and MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Mrtf in Genome Data Viewer
    Location:
    62F2-62F3; 3-4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2717615..2766536, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2717615..2766480, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fife Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 62F Neighboring gene Adenosylhomocysteinase like 1 Neighboring gene Novel nucleolar protein 2

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Myocardin-related transcription factor
    Names
    CG32296-PD
    CG32296-PG
    CG32296-PH
    Mrtf-PD
    Mrtf-PG
    Mrtf-PH
    myocardin-related transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2717615..2766536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259651.3NP_001246580.1  Myocardin-related transcription factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6B4I4, Q9VZY2
      Conserved Domains (2) summary
      smart00707
      Location:94119
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:578612
      SAP; SAP domain
    2. NM_001144407.4NP_001137879.3  Myocardin-related transcription factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137879.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z043, Q6B4I4
      Conserved Domains (2) summary
      smart00707
      Location:387412
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:871905
      SAP; SAP domain
    3. NM_001144406.3NP_001137878.2  Myocardin-related transcription factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137878.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6B4I4, Q9VZY2
      Conserved Domains (2) summary
      smart00707
      Location:94119
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:578612
      SAP; SAP domain