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    Mrtf Myocardin-related transcription factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrtfprovided by FlyBase
    Official Full Name
    Myocardin-related transcription factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052296
    Locus tag
    Dmel_CG32296
    See related
    AllianceGenome:FB:FBgn0052296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12188; CG14951; CG32296; Dmel\CG32296; dMrtf; dMRTF; DMRTF; mal; mal-d; Mal-D; MAL-D; MRTF
    Summary
    Enables DNA-binding transcription factor binding activity and transcription coactivator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including border follicle cell migration; cellular response to hypoxia; and mesodermal cell migration. Located in cytoplasm and nucleus. Is expressed in several structures, including border follicle cell; egg chamber; larval muscle cell; and ovary. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia; congenital megabladder; dilated cardiomyopathy; and immunodeficiency 66. Orthologous to human MYOCD (myocardin); MRTFA (myocardin related transcription factor A); and MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mrtf in Genome Data Viewer
    Location:
    62F2-62F3; 3-4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2717615..2766536, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2717615..2766480, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fife Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 62F Neighboring gene Adenosylhomocysteinase like 1 Neighboring gene Novel nucleolar protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. Andrews JC, et al. Genet Med, 2023 Jun. PMID 37013900, Free PMC Article
    2. The core and conserved role of MAL is homeostatic regulation of actin levels. Salvany L, et al. Genes Dev, 2014 May 15. PMID 24831700, Free PMC Article
    3. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Pipes GC, et al. Genes Dev, 2006 Jun 15. PMID 16778073
    4. Mal/SRF is dispensable for cell proliferation in Drosophila. Thompson BJ. PLoS One, 2010 Apr 9. PMID 20404916, Free PMC Article
    5. Novel ability of diflubenzuron as an inhibitor of mitochondrial function. Mori K, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38342197

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in both Drosophila and human cellular models that actin is the key target that must be regulated by MAL/SRF for invasive cell migration
      Title: The core and conserved role of MAL is homeostatic regulation of actin levels.
    2. Border cell migration requires the activity of MAL-D and nuclear accumulation of MAL-D is induced by cell stretching.
      Title: Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.
    3. Data describe a myocardin-related transcription factor from Drosophila, DMRTF, which is shares homology with mammalian myocardin and MRTFs and stimulates the activity of Drosophila serum response factor
      Title: A myocardin-related transcription factor regulates activity of serum response factor in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myocardin-related transcription factor
    Names
    CG32296-PD
    CG32296-PG
    CG32296-PH
    Mrtf-PD
    Mrtf-PG
    Mrtf-PH
    myocardin-related transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2717615..2766536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259651.3 → NP_001246580.1  Myocardin-related transcription factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6B4I4, Q9VZY2
      Conserved Domains (2) summary
      smart00707
      Location:94 → 119
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:578 → 612
      SAP; SAP domain

    2. NM_001144407.4 → NP_001137879.3  Myocardin-related transcription factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137879.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z043, Q6B4I4
      Conserved Domains (2) summary
      smart00707
      Location:387 → 412
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:871 → 905
      SAP; SAP domain

    3. NM_001144406.3 → NP_001137878.2  Myocardin-related transcription factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137878.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6B4I4, Q9VZY2
      Conserved Domains (2) summary
      smart00707
      Location:94 → 119
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:578 → 612
      SAP; SAP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z043 B7Z043
    Q6B4I4 Q6B4I4
    Q8MZ79 Q8MZ79
    Q9VZY2 Q9VZY2

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