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    MRTFB myocardin related transcription factor B [ Homo sapiens (human) ]

    Gene ID: 57496, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRTFBprovided by HGNC
    Official Full Name
    myocardin related transcription factor Bprovided by HGNC
    Primary source
    HGNC:HGNC:29819
    See related
    Ensembl:ENSG00000186260 MIM:609463; AllianceGenome:HGNC:29819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKL2; MRTF-B; NPD001
    Summary
    Enables transcription coactivator activity. Involved in positive regulation of miRNA transcription; positive regulation of striated muscle tissue development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 11.0), testis (RPKM 5.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRTFB in Genome Data Viewer
    Location:
    16p13.12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (13994774..14266779)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (14032048..14304042)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14164919..14360636)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371093 Neighboring gene uncharacterized LOC124903647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10487 Neighboring gene ribosomal protein S26 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7223 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:14050534-14051733 Neighboring gene ERCC excision repair 4, endonuclease catalytic subunit Neighboring gene long intergenic non-protein coding RNA 2185 Neighboring gene long intergenic non-protein coding RNA 2186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14144523-14145135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10490 Neighboring gene uncharacterized LOC124903783 Neighboring gene TVP23C pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:14339016-14340215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:14375643-14376144 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:14377689-14378337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14379019-14380016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10491 Neighboring gene Sharpr-MPRA regulatory region 5476 Neighboring gene tRNA-Thr (anticodon CGT) 2-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7229 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:14396656-14396816 Neighboring gene MIR193b-365a host gene Neighboring gene microRNA 193b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions. Dickson BC, et al. Am J Surg Pathol, 2018 Oct. PMID 29912715, Free PMC Article
    2. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Cen B, et al. Mol Cell Biol, 2003 Sep. PMID 12944485, Free PMC Article
    3. Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells. Smith MC, et al. Sci Rep, 2017 Jun 16. PMID 28623279, Free PMC Article
    4. The MRTF-A/B function as oncogenes in pancreatic cancer. Song Z, et al. Oncol Rep, 2016 Jan. PMID 26498848
    5. Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. Hampl V, et al. EMBO Mol Med, 2013 Sep. PMID 23853104, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
      Title: KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
    2. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
      Title: De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
    3. Role of CRP2-MRTF interaction in functions of myofibroblasts.
      Title: Role of CRP2-MRTF interaction in functions of myofibroblasts.
    4. Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.
      Title: Oxidative Stress Enhances the TGF-β2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.
    5. The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.
      Title: The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.
    6. Lower MRTFB expression levels are associated with shorter survival of patients with GI tract cancer. MRTFB targets SPDL1 and MCAM to inhibit CRC cell motility and tumor growth. Depletion of MRTFB in human CRC Cells increases cell motility and accelerates tumor growth in xenograft assays.
      Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
    7. Ectomesenchymal chondromyxoid tumors are characterized by an RREB1-MKL2 fusion gene.
      Title: Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions.
    8. These studies implicate the actin cytoskeleton and ELK3, FLI1, and MKL2 in the transcriptional control of EDNRB and increase our understanding of the plasticity of this receptor
      Title: Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics.
    9. Our new data identifies and important contribution of MKL1/2 to explaining the strikingly different response of VSMCs and ECs to cAMP elevation. Elucidation of these pathways promises to identify targets for specific inhibition of VSMC migration and proliferation.
      Title: Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells.
    10. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation.
      Title: Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    EBI GWAS Catalog
    Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that MKL2 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with MKL2 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31823, FLJ45623, DKFZp686J1745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of miRNA transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myocardin-related transcription factor B
    Names
    CTA-276F8.1
    MKL and myocardin family member 2
    MKL/myocardin like 2
    MKL/myocardin-like protein 2
    MKL1/myocardin like 2
    megakaryoblastic leukemia 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308142.2 → NP_001295071.1  myocardin-related transcription factor B isoform 1

      See identical proteins and their annotated locations for NP_001295071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC012626, AC040173, AC130650
      Consensus CDS
      CCDS76823.1
      UniProtKB/Swiss-Prot
      Q9ULH7
      Related
      ENSP00000459626.2, ENST00000571589.6
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    2. NM_001365411.2 → NP_001352340.1  myocardin-related transcription factor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      UniProtKB/Swiss-Prot
      A6ND53, B4DGT8, Q68CT1, Q6UB16, Q86WW2, Q8N226, Q9ULH7
      Conserved Domains (5) summary
      smart00707
      Location:128 → 153
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:389 → 422
      SAP; SAP domain
      pfam02755
      Location:85 → 107
      RPEL; RPEL repeat
      cl26464
      Location:186 → 399
      Atrophin-1; Atrophin-1 family
      cl26585
      Location:557 → 594
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

    3. NM_001365412.2 → NP_001352341.1  myocardin-related transcription factor B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    4. NM_001365413.2 → NP_001352342.1  myocardin-related transcription factor B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      Conserved Domains (6) summary
      smart00707
      Location:68 → 93
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:126 → 339
      PHA03247; large tegument protein UL36; Provisional
      TIGR02784
      Location:121 → 203
      addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
      pfam02037
      Location:332 → 362
      SAP; SAP domain
      pfam02755
      Location:25 → 48
      RPEL; RPEL repeat
      pfam09903
      Location:497 → 534
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

    5. NM_001365414.2 → NP_001352343.1  myocardin-related transcription factor B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      Conserved Domains (7) summary
      smart00707
      Location:68 → 93
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:329 → 362
      SAP; SAP domain
      pfam02755
      Location:25 → 47
      RPEL; RPEL repeat
      cl26464
      Location:126 → 339
      Atrophin-1; Atrophin-1 family
      cl26585
      Location:497 → 534
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl28087
      Location:538 → 725
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
      cl28312
      Location:121 → 203
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

    6. NM_001365415.2 → NP_001352344.1  myocardin-related transcription factor B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      Consensus CDS
      CCDS92112.1
      UniProtKB/TrEMBL
      I3L2S3
      Related
      ENSP00000459879.1, ENST00000572567.5
      Conserved Domains (3) summary
      smart00707
      Location:128 → 153
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:85 → 107
      RPEL; RPEL repeat
      cl26464
      Location:186 → 310
      Atrophin-1; Atrophin-1 family

    7. NM_001365416.2 → NP_001352345.1  myocardin-related transcription factor B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC012626, AC040173, AC130650
      Conserved Domains (3) summary
      smart00707
      Location:68 → 93
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:25 → 47
      RPEL; RPEL repeat
      cl28312
      Location:121 → 203
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

    8. NM_001365417.3 → NP_001352346.1  myocardin-related transcription factor B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC130650

    9. NM_001365418.3 → NP_001352347.1  myocardin-related transcription factor B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC130650

    10. NM_001365419.3 → NP_001352348.1  myocardin-related transcription factor B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC130650

    11. NM_001365420.3 → NP_001352349.1  myocardin-related transcription factor B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC130650

    12. NM_001365421.3 → NP_001352350.1  myocardin-related transcription factor B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC130650

    13. NM_014048.4 → NP_054767.3  myocardin-related transcription factor B isoform 2

      See identical proteins and their annotated locations for NP_054767.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC040173, AC130650, AY374297, BC016293
      Consensus CDS
      CCDS32391.1
      UniProtKB/Swiss-Prot
      Q9ULH7
      Related
      ENSP00000459205.1, ENST00000574045.5
      Conserved Domains (8) summary
      smart00707
      Location:139 → 164
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:609 → 796
      PRK10263; DNA translocase FtsK; Provisional
      TIGR02784
      Location:192 → 274
      addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
      pfam02037
      Location:403 → 433
      SAP; SAP domain
      pfam02755
      Location:96 → 119
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 605
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      13994774..14266779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434393.1 → XP_047290349.1  myocardin-related transcription factor B isoform X1

    2. XM_047434392.1 → XP_047290348.1  myocardin-related transcription factor B isoform X1

    3. XM_017023501.3 → XP_016878990.1  myocardin-related transcription factor B isoform X1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    4. XM_047434402.1 → XP_047290358.1  myocardin-related transcription factor B isoform X4

      Related
      ENSP00000339086.4, ENST00000318282.9

    5. XM_047434391.1 → XP_047290347.1  myocardin-related transcription factor B isoform X1

    6. XM_047434390.1 → XP_047290346.1  myocardin-related transcription factor B isoform X1

    7. XM_047434399.1 → XP_047290355.1  myocardin-related transcription factor B isoform X3

    8. XM_005255452.4 → XP_005255509.1  myocardin-related transcription factor B isoform X1

      See identical proteins and their annotated locations for XP_005255509.1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    9. XM_006720914.3 → XP_006720977.1  myocardin-related transcription factor B isoform X4

      See identical proteins and their annotated locations for XP_006720977.1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (8) summary
      smart00707
      Location:139 → 164
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:609 → 796
      PRK10263; DNA translocase FtsK; Provisional
      TIGR02784
      Location:192 → 274
      addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
      pfam02037
      Location:403 → 433
      SAP; SAP domain
      pfam02755
      Location:96 → 119
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 605
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat

    10. XM_047434398.1 → XP_047290354.1  myocardin-related transcription factor B isoform X3

    11. XM_047434405.1 → XP_047290361.1  myocardin-related transcription factor B isoform X7

    12. XM_006720909.5 → XP_006720972.1  myocardin-related transcription factor B isoform X1

      See identical proteins and their annotated locations for XP_006720972.1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    13. XM_011522568.3 → XP_011520870.1  myocardin-related transcription factor B isoform X1

      See identical proteins and their annotated locations for XP_011520870.1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    14. XM_047434400.1 → XP_047290356.1  myocardin-related transcription factor B isoform X3

    15. XM_047434403.1 → XP_047290359.1  myocardin-related transcription factor B isoform X4

    16. XM_047434397.1 → XP_047290353.1  myocardin-related transcription factor B isoform X1

    17. XM_047434394.1 → XP_047290350.1  myocardin-related transcription factor B isoform X1

    18. XM_047434395.1 → XP_047290351.1  myocardin-related transcription factor B isoform X1

    19. XM_017023502.1 → XP_016878991.1  myocardin-related transcription factor B isoform X1

      UniProtKB/Swiss-Prot
      Q9ULH7
      Conserved Domains (6) summary
      PHA03247
      Location:197 → 410
      PHA03247; large tegument protein UL36; Provisional
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:141 → 163
      RPEL; RPEL repeat
      pfam09903
      Location:568 → 628
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:52 → 76
      RPEL; RPEL repeat
      cl41773
      Location:649 → 826
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    20. XM_047434396.1 → XP_047290352.1  myocardin-related transcription factor B isoform X1

    21. XM_047434401.1 → XP_047290357.1  myocardin-related transcription factor B isoform X3

    22. XM_017023503.3 → XP_016878992.1  myocardin-related transcription factor B isoform X2

      Conserved Domains (7) summary
      smart00707
      Location:102 → 127
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:160 → 373
      PHA03247; large tegument protein UL36; Provisional
      TIGR02784
      Location:155 → 237
      addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
      pfam02037
      Location:366 → 396
      SAP; SAP domain
      pfam02755
      Location:59 → 82
      RPEL; RPEL repeat
      pfam09903
      Location:531 → 568
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
      cl29414
      Location:15 → 39
      RPEL; RPEL repeat

    23. XM_017023504.2 → XP_016878993.1  myocardin-related transcription factor B isoform X5

      Conserved Domains (6) summary
      smart00707
      Location:128 → 153
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:186 → 399
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:598 → 785
      PRK10263; DNA translocase FtsK; Provisional
      pfam02037
      Location:392 → 422
      SAP; SAP domain
      pfam02755
      Location:85 → 108
      RPEL; RPEL repeat
      pfam09903
      Location:557 → 594
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

    24. XM_047434404.1 → XP_047290360.1  myocardin-related transcription factor B isoform X6

    25. XM_011522569.3 → XP_011520871.1  myocardin-related transcription factor B isoform X6

      See identical proteins and their annotated locations for XP_011520871.1

      Conserved Domains (6) summary
      smart00707
      Location:68 → 93
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:126 → 339
      PHA03247; large tegument protein UL36; Provisional
      TIGR02784
      Location:121 → 203
      addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
      pfam02037
      Location:332 → 362
      SAP; SAP domain
      pfam02755
      Location:25 → 48
      RPEL; RPEL repeat
      pfam09903
      Location:497 → 534
      DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      14032048..14304042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313537.1 → XP_054169512.1  myocardin-related transcription factor B isoform X1

    2. XM_054313536.1 → XP_054169511.1  myocardin-related transcription factor B isoform X1

    3. XM_054313538.1 → XP_054169513.1  myocardin-related transcription factor B isoform X1

    4. XM_054313553.1 → XP_054169528.1  myocardin-related transcription factor B isoform X4

    5. XM_054313535.1 → XP_054169510.1  myocardin-related transcription factor B isoform X1

    6. XM_054313545.1 → XP_054169520.1  myocardin-related transcription factor B isoform X1

    7. XM_054313549.1 → XP_054169524.1  myocardin-related transcription factor B isoform X3

    8. XM_054313543.1 → XP_054169518.1  myocardin-related transcription factor B isoform X1

    9. XM_054313552.1 → XP_054169527.1  myocardin-related transcription factor B isoform X4

    10. XM_054313548.1 → XP_054169523.1  myocardin-related transcription factor B isoform X3

    11. XM_054313558.1 → XP_054169533.1  myocardin-related transcription factor B isoform X7

    12. XM_054313534.1 → XP_054169509.1  myocardin-related transcription factor B isoform X1

    13. XM_054313539.1 → XP_054169514.1  myocardin-related transcription factor B isoform X1

    14. XM_054313550.1 → XP_054169525.1  myocardin-related transcription factor B isoform X3

    15. XM_054313554.1 → XP_054169529.1  myocardin-related transcription factor B isoform X4

    16. XM_054313546.1 → XP_054169521.1  myocardin-related transcription factor B isoform X1

    17. XM_054313540.1 → XP_054169515.1  myocardin-related transcription factor B isoform X1

    18. XM_054313542.1 → XP_054169517.1  myocardin-related transcription factor B isoform X1

    19. XM_054313541.1 → XP_054169516.1  myocardin-related transcription factor B isoform X1

    20. XM_054313544.1 → XP_054169519.1  myocardin-related transcription factor B isoform X1

    21. XM_054313551.1 → XP_054169526.1  myocardin-related transcription factor B isoform X3

    22. XM_054313547.1 → XP_054169522.1  myocardin-related transcription factor B isoform X2

    23. XM_054313555.1 → XP_054169530.1  myocardin-related transcription factor B isoform X5

    24. XM_054313557.1 → XP_054169532.1  myocardin-related transcription factor B isoform X6

    25. XM_054313556.1 → XP_054169531.1  myocardin-related transcription factor B isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULH7.3 GenPept UniProtKB/Swiss-Prot:Q9ULH7

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