RPL9 ribosomal protein L9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPL9provided by HGNC
Official Full Name: ribosomal protein L9provided by HGNC
Primary source: HGNC:HGNC:10369
See related: Ensembl:ENSG00000163682 MIM:603686; AllianceGenome:HGNC:10369
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L9; uL6; NPC-A-16
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression: Ubiquitous expression in ovary (RPKM 1269.0), bone marrow (RPKM 646.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (39454124..39458922, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (39423773..39428574, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (39455744..39460542, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
Title: RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
Title: Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
Title: Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
Here we report an individual diagnosed with DBA carrying a variant in the 5'UTR of RPL9 (uL6). Additionally, we report two individuals from a family with multiple cancer incidences carrying a RPL9 missense variant
Title: Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
UNR could bind to the 3'UTR of PTEN and RPL9 in glioma cell lines, therefore promoting glioma cell migration and regulating the expression of RPL9.
Title: RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9.
High RPL9 expression is associated with colorectal carcinoma.
Title: Knockdown of RPL9 expression inhibits colorectal carcinoma growth via the inactivation of Id-1/NF-κB signaling axis.
The authors propose that during rabies virus infection, viral phosphoprotein P binds to ribosomal protein L9 that translocates from the nucleus to the cytoplasm, inhibiting the initial stage of viral transcription.
Title: Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L9 (RPL9) at amino acid residues 42-43 and 45-46 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-59408 (e-PCR)
- UniSTS:6200

D4S3187 (e-PCR)
- UniSTS:28767

RH67836 (e-PCR)
- UniSTS:84205

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	HDA more info	PubMed
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in ribosome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein uL6

Names: 60S ribosomal protein L9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052985.1 RefSeqGene

Range

5027..9825

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1142

mRNA and Protein(s)

NM_000661.5 → NP_000652.2 large ribosomal subunit protein uL6

See identical proteins and their annotated locations for NP_000652.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and the predominant variant. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC031906, BC066318, BM841336

Consensus CDS

CCDS3452.1

UniProtKB/Swiss-Prot

P32969

UniProtKB/TrEMBL

A0A024R9U2, D6RAN4, Q53Z07

Related

ENSP00000346022.7, ENST00000295955.14

Conserved Domains (1) summary

cl30086
Location:1 → 191

Ribosomal_L6; Ribosomal protein L6
NM_001024921.4 → NP_001020092.1 large ribosomal subunit protein uL6

See identical proteins and their annotated locations for NP_001020092.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternative splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL039355, AY376242, BC031906

Consensus CDS

CCDS3452.1

UniProtKB/Swiss-Prot

P32969

UniProtKB/TrEMBL

A0A024R9U2, D6RAN4, Q53Z07

Related

ENSP00000494697.1, ENST00000645496.2

Conserved Domains (1) summary

cl30086
Location:1 → 191

Ribosomal_L6; Ribosomal protein L6