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    ND-20 NADH dehydrogenase (ubiquinone) 20 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-20provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 20 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030718
    Locus tag
    Dmel_CG9172
    See related
    AllianceGenome:FB:FBgn0030718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    20 kDa; CG9172; Dmel\CG9172; Dmel_CG9172; dNDUFS7; dNDUFS7A; ND20; NDUFS7; NUKM; PSST
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including determination of adult lifespan; mitochondrial respiratory chain complex I assembly; and regulation of terminal button organization. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex I deficiency and nuclear type mitochondrial complex I deficiency 3. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-20 in Genome Data Viewer
    Location:
    14A5-14A5; 1-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15985473..15986808, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15879506..15880841, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene Solute carrier family 25 member 46a Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene extradenticle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model. Christen M, et al. Sci Rep, 2024 Feb 5. PMID 38316835, Free PMC Article
    2. A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urticae is associated with resistance to METI acaricides. Bajda S, et al. Insect Biochem Mol Biol, 2017 Jan. PMID 27919778
    3. RNAi of Complex I and V of the electron transport chain in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster. Landis JE, et al. PLoS One, 2023. PMID 37319260, Free PMC Article
    4. Drosophila Prominin-like, a homolog of CD133, interacts with ND20 to maintain mitochondrial function. Wang X, et al. Cell Biosci, 2019. PMID 31890150, Free PMC Article
    5. A Drosophila Mitochondrial Complex I Deficiency Phenotype Array. Foriel S, et al. Front Genet, 2019. PMID 30972103, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 20 kDa subunit
    Names
    CG9172-PA
    CG9172-PB
    CG9172-PC
    FBpp0073949
    NADH ubiquinone oxidoreductase 20 kDa
    NADH-UBIQUINONE OXIDOREDUCTASE 20 KDA SUBUNIT
    NADH:ubiquinone oxidoreductase 20 kDa subunit
    ND-20-PA
    ND-20-PB
    ND-20-PC
    NP_001285313.1
    NP_573097.1
    NP_727921.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15985473..15986808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298384.1 → NP_001285313.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXK7
      Conserved Domains (1) summary
      PRK06411
      Location:72 → 213
      PRK06411; NADH dehydrogenase subunit B; Validated

    2. NM_132869.4 → NP_573097.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXK7
      Related
      FBpp0073949
      Conserved Domains (1) summary
      PRK06411
      Location:72 → 213
      PRK06411; NADH dehydrogenase subunit B; Validated

    3. NM_167476.2 → NP_727921.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXK7
      Related
      FBpp0073950
      Conserved Domains (1) summary
      PRK06411
      Location:72 → 213
      PRK06411; NADH dehydrogenase subunit B; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXK7 Q9VXK7

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