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    CadN2 Cadherin-N2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CadN2provided by FlyBase
    Official Full Name
    Cadherin-N2provided by FlyBase
    Primary source
    FLYBASE:FBgn0262018
    Locus tag
    Dmel_CG42829
    See related
    AllianceGenome:FB:FBgn0262018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cadN2; CG42829; CG7527; CT23007; Dmel\CG42829; DmNCad2; DN-cad2; DN-Cad2; DN-like; DNcad2; N-Cad2; Ncad2; NCad2
    Old locus tag
    Dmel_CG7527
    Summary
    Predicted to enable beta-catenin binding activity; cadherin binding activity; and calcium ion binding activity. Involved in axon extension involved in axon guidance and compound eye morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Is expressed in adult head. Orthologous to human CDH26 (cadherin 26). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CadN2 in Genome Data Viewer
    Location:
    36D3-36E1; 2-53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17786971..17875247, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17786971..17875247, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45699 Neighboring gene Cadherin-N Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43419 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43420 Neighboring gene long non-coding RNA:CR45332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents. Yonekura S, et al. Dev Biol, 2007 Apr 15. PMID 17320070, Free PMC Article
    2. Evolution: structural and functional diversity of cadherin at the adherens junction. Oda H, et al. J Cell Biol, 2011 Jun 27. PMID 21708975, Free PMC Article
    3. The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development. Biersmith B, et al. PLoS One, 2011 Jan 25. PMID 21283588, Free PMC Article
    4. Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Prakash S, et al. Nat Neurosci, 2005 Apr. PMID 15735641, Free PMC Article
    5. Epigenetic control of learning and memory in Drosophila by Tip60 HAT action. Xu S, et al. Genetics, 2014 Dec. PMID 25326235, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c17825122-17819978 mobile_element_type = transposon:copia{}399

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R8 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cadherin-N2
    Names
    CG42829-PC
    CG42829-PD
    CadN2-PC
    CadN2-PD
    DN-cadh-like
    DN-cadherin
    N-cadherin2
    cadherin N2r

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17786971..17875247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136011.4 → NP_609855.3  Cadherin-N2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609855.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4LU36, Q0E8P8, Q9VJB6
      Conserved Domains (6) summary
      cd11304
      Location:489 → 586
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:1497 → 1535
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1013 → 1198
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01049
      Location:1583 → 1719
      Cadherin_C; Cadherin cytoplasmic region
      pfam02210
      Location:1293 → 1428
      Laminin_G_2; Laminin G domain
      pfam07974
      Location:1233 → 1259
      EGF_2; EGF-like domain

    2. NM_001042903.4 → NP_001036368.2  Cadherin-N2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036368.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4LU36, Q0E8P8, Q9VJB6
      Conserved Domains (6) summary
      cd11304
      Location:489 → 586
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:1497 → 1535
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1013 → 1198
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01049
      Location:1583 → 1719
      Cadherin_C; Cadherin cytoplasmic region
      pfam02210
      Location:1293 → 1428
      Laminin_G_2; Laminin G domain
      pfam07974
      Location:1233 → 1259
      EGF_2; EGF-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJB6.3 Q9VJB6

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