U.S. flag

An official website of the United States government

Links from Nucleotide

    • Showing Current items.

    Stat5b signal transducer and activator of transcription 5B [ Mus musculus (house mouse) ]

    Gene ID: 20851, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat5bprovided by MGI
    Official Full Name
    signal transducer and activator of transcription 5Bprovided by MGI
    Primary source
    MGI:MGI:103035
    See related
    Ensembl:ENSMUSG00000020919 AllianceGenome:MGI:103035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on taurine metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 41.1), ovary adult (RPKM 18.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stat5b in Genome Data Viewer
    Location:
    11 D; 11 63.63 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100671557..100741407, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100780731..100859004, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene STARR-positive B cell enhancer ABC_E8453 Neighboring gene hypocretin Neighboring gene GH3 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E8454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100681071-100681254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100707044-100707332 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100753050-100753254 Neighboring gene STARR-positive B cell enhancer ABC_E8455 Neighboring gene signal transducer and activator of transcription 3 Neighboring gene STARR-positive B cell enhancer ABC_E5279 Neighboring gene STARR-seq mESC enhancer starr_30745 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100800942-100801125 Neighboring gene predicted gene, 46295

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables chromatin binding  
    enables chromatin binding  
    enables double-stranded DNA binding  
    enables identical protein binding  
    enables nuclear glucocorticoid receptor binding  
    enables nuclear glucocorticoid receptor binding  
    enables protein binding PubMed 
    enables protein dimerization activity PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables sequence-specific DNA binding  
    Items 1 - 25 of 91
    Process Evidence Code Pubs
    acts_upstream_of B cell differentiation PubMed 
    acts_upstream_of_or_within Peyer's patch development PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell homeostasis PubMed 
    acts_upstream_of activated T cell proliferation PubMed 
    acts_upstream_of activated T cell proliferation PubMed 
    involved_in acute-phase response  
    acts_upstream_of cell population proliferation PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to hormone stimulus  
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in defense response  
    acts_upstream_of_or_within development of secondary female sexual characteristics PubMed 
    acts_upstream_of_or_within development of secondary male sexual characteristics PubMed 
    acts_upstream_of_or_within development of secondary male sexual characteristics PubMed 
    acts_upstream_of erythrocyte differentiation PubMed 
    involved_in erythropoietin-mediated signaling pathway  
    acts_upstream_of_or_within female pregnancy PubMed 
    acts_upstream_of_or_within female pregnancy PubMed 
    acts_upstream_of gamma-delta T cell differentiation PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    acts_upstream_of interleukin-2 production PubMed 
    acts_upstream_of_or_within lactation PubMed 
    acts_upstream_of_or_within lipid storage PubMed 
    involved_in liver development  
    acts_upstream_of_or_within luteinization PubMed 
    involved_in luteinization  
    acts_upstream_of lymphocyte differentiation PubMed 
    acts_upstream_of_or_within mast cell migration PubMed 
    acts_upstream_of mitotic cell cycle PubMed 
    acts_upstream_of myeloid cell apoptotic process PubMed 
    acts_upstream_of_or_within natural killer cell differentiation PubMed 
    acts_upstream_of natural killer cell differentiation PubMed 
    acts_upstream_of natural killer cell mediated cytotoxicity PubMed 
    acts_upstream_of natural killer cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of erythrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of B cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of activated T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of activated T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of fibroblast growth factor production  
    acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation PubMed 
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-2 production PubMed 
    acts_upstream_of_or_within positive regulation of lymphocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of mitotic cell cycle PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell proliferation PubMed 
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within progesterone metabolic process PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell adhesion PubMed 
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of epithelial cell differentiation PubMed 
    involved_in regulation of multicellular organism growth PubMed 
    acts_upstream_of_or_within regulation of steroid metabolic process PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in response to estradiol  
    involved_in response to estradiol  
    acts_upstream_of_or_within response to interleukin-15 PubMed 
    acts_upstream_of_or_within response to interleukin-2 PubMed 
    acts_upstream_of_or_within response to interleukin-4 PubMed 
    involved_in response to lipopolysaccharide  
    involved_in response to peptide hormone  
    involved_in response to peptide hormone  
    acts_upstream_of_or_within sex differentiation PubMed 
    acts_upstream_of_positive_effect taurine metabolic process PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    Items 1 - 25 of 91
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    signal transducer and activator of transcription 5B
    Names
    mammary gland factor STAT5B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113563.2NP_001107035.1  signal transducer and activator of transcription 5B

      See identical proteins and their annotated locations for NP_001107035.1

      Status: VALIDATED

      Source sequence(s)
      AI414876, AK045531, AK150098, AL591466
      Consensus CDS
      CCDS25438.1
      UniProtKB/Swiss-Prot
      A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8
      Related
      ENSMUSP00000004143.3, ENSMUST00000004143.3
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    2. NM_001362682.1NP_001349611.1  signal transducer and activator of transcription 5B

      Status: VALIDATED

      Source sequence(s)
      AL591466
      Consensus CDS
      CCDS25438.1
      UniProtKB/Swiss-Prot
      A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    3. NM_011489.3NP_035619.3  signal transducer and activator of transcription 5B

      See identical proteins and their annotated locations for NP_035619.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI414876, AK045531, AK150098, AL591466
      Consensus CDS
      CCDS25438.1
      UniProtKB/Swiss-Prot
      A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8
      Related
      ENSMUSP00000102981.3, ENSMUST00000107358.9
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100671557..100741407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.