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    GBP2 guanylate binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 2634, updated on 10-Dec-2024

    Summary

    Official Symbol
    GBP2provided by HGNC
    Official Full Name
    guanylate binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:4183
    See related
    Ensembl:ENSG00000162645 MIM:600412; AllianceGenome:HGNC:4183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in appendix (RPKM 36.9), urinary bladder (RPKM 31.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GBP2 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89106132..89126114, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (88949485..88969475, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89571815..89591797, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378841 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:89521826-89523025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1295 Neighboring gene guanylate binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 5145 Neighboring gene prostaglandin E synthase 3 pseudogene 1 Neighboring gene uncharacterized LOC112268267 Neighboring gene Sharpr-MPRA regulatory region 4932 Neighboring gene uncharacterized LOC105378842 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89614414-89615613 Neighboring gene guanylate binding protein 7 Neighboring gene uncharacterized LOC107985076 Neighboring gene Sharpr-MPRA regulatory region 13956 Neighboring gene guanylate binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 2, interferon-inducible (GBP2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: GBP7

    Clone Names

    • DKFZp451C2311

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables endopeptidase inhibitor activity PubMed 
    enables identical protein binding PubMed 
    enables membrane scission GTPase motor activity  
    enables molecular function inhibitor activity PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    Process Evidence Code Pubs
    involved_in activation of innate immune response  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in cellular response to type II interferon  
    involved_in cellular response to type II interferon PubMed 
    involved_in cytolysis in another organism  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to bacterium  
    involved_in defense response to protozoan  
    involved_in defense response to virus PubMed 
    involved_in immune response PubMed 
    involved_in positive regulation of AIM2 inflammasome complex assembly  
    involved_in positive regulation of pyroptotic inflammatory response  
    involved_in protein localization to nucleus PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus PubMed 
    located_in Golgi apparatus PubMed 
    is_active_in Golgi membrane PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    guanylate-binding protein 2
    Names
    GTP-binding protein 2
    guanine nucleotide-binding protein 2
    guanylate binding protein 2, interferon-inducible
    interferon-induced guanylate-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046995.1 RefSeqGene

      Range
      5046..25028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004120.5 → NP_004111.2  guanylate-binding protein 2

      See identical proteins and their annotated locations for NP_004111.2

      Status: REVIEWED

      Source sequence(s)
      AC104459, AI085798, AI400402, AI445567, BC022272, BC073163, BM993865, DB229415, DB274428
      Consensus CDS
      CCDS719.1
      UniProtKB/Swiss-Prot
      P32456, Q6GPH0, Q6IAU2, Q86TB0
      UniProtKB/TrEMBL
      Q8TCE5
      Related
      ENSP00000359497.3, ENST00000370466.4
      Conserved Domains (2) summary
      pfam02263
      Location:18 → 280
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:282 → 578
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      89106132..89126114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      88949485..88969475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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