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    UCHL5 ubiquitin C-terminal hydrolase L5 [ Homo sapiens (human) ]

    Gene ID: 51377, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UCHL5provided by HGNC
    Official Full Name
    ubiquitin C-terminal hydrolase L5provided by HGNC
    Primary source
    HGNC:HGNC:19678
    See related
    Ensembl:ENSG00000116750 MIM:610667; AllianceGenome:HGNC:19678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UCH37; CGI-70; INO80R; UCH-L5
    Summary
    Enables cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UCHL5 in Genome Data Viewer
    Location:
    1q31.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (193012254..193060076, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (192359462..192407284, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192981384..193029206, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RSG2 antisense RNA 1 Neighboring gene zinc finger protein 101 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:192979786-192979951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2265 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028176-193028908 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193028909-193029641 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene Ro60, Y RNA binding protein Neighboring gene Sharpr-MPRA regulatory region 7925 Neighboring gene uncharacterized LOC124904474 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:193082253-193083159 Neighboring gene Sharpr-MPRA regulatory region 4625 Neighboring gene glutaredoxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/β-catenin pathway. Wan B, et al. BMC Cancer, 2024 May 21. PMID 38773433, Free PMC Article
    2. High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer. Wang L, et al. Tumour Biol, 2014 Nov. PMID 25123264
    3. Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma. Chen Y, et al. Dig Dis Sci, 2012 Sep. PMID 22615012
    4. Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma. Arpalahti L, et al. Tumour Biol, 2017 Jun. PMID 28653876
    5. UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Arpalahti L, et al. Tumour Biol, 2017 Jul. PMID 28681694

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/beta-catenin pathway.
      Title: UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/β-catenin pathway.
    2. The TGF-beta/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.
      Title: The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.
    3. MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
      Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
    4. Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
      Title: Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
    5. A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.
      Title: A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.
    6. UCHL5 controls beta-catenin destruction complex function through Axin1 regulation.
      Title: UCHL5 controls β-catenin destruction complex function through Axin1 regulation.
    7. Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.
      Title: Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.
    8. Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
      Title: Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
    9. LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
      Title: LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
    10. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
      Title: Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of DSM-IV cannabis dependence.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables endopeptidase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in forebrain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lateral ventricle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in midbrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    Names
    INO80 complex subunit R
    ubiquitin C-terminal hydrolase UCH37
    ubiquitin carboxyl-terminal esterase L5
    ubiquitin carboxyl-terminal hydrolase L5
    ubiquitin thioesterase L5
    NP_001186190.1
    NP_001186191.1
    NP_001186192.1
    NP_001337769.1
    NP_001337770.1
    NP_001337771.1
    NP_001337772.1
    NP_001337773.1
    NP_001337774.1
    NP_001337775.1
    NP_001337776.1
    NP_001337777.1
    NP_001337778.1
    NP_001337779.1
    NP_001337780.1
    NP_001337781.1
    NP_057068.1
    XP_006711430.2
    XP_006711432.2
    XP_006711433.3
    XP_006711434.1
    XP_011507906.2
    XP_011507909.1
    XP_016856922.2
    XP_016856927.1
    XP_047278266.1
    XP_047278278.1
    XP_047278280.1
    XP_047278285.1
    XP_047278289.1
    XP_047278300.1
    XP_047278309.1
    XP_047278316.1
    XP_047278319.1
    XP_047278322.1
    XP_047278327.1
    XP_047278328.1
    XP_054192913.1
    XP_054192914.1
    XP_054192915.1
    XP_054192916.1
    XP_054192917.1
    XP_054192918.1
    XP_054192919.1
    XP_054192920.1
    XP_054192921.1
    XP_054192922.1
    XP_054192923.1
    XP_054192924.1
    XP_054192925.1
    XP_054192926.1
    XP_054192927.1
    XP_054192928.1
    XP_054192929.1
    XP_054192930.1
    XP_054192931.1
    XP_054192932.1
    XP_054192933.1
    XP_054192934.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199261.3 → NP_001186190.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

      See identical proteins and their annotated locations for NP_001186190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AL136370, BC015521, BP397519, DA255130
      Consensus CDS
      CCDS55668.1
      UniProtKB/TrEMBL
      B2RB07
      Related
      ENSP00000356424.1, ENST00000367454.6
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:263 → 308
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    2. NM_001199262.3 → NP_001186191.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3

      See identical proteins and their annotated locations for NP_001186191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL136370, BC025369, DN916480
      Consensus CDS
      CCDS55670.1
      UniProtKB/TrEMBL
      B2RB07
      Related
      ENSP00000356418.1, ENST00000367448.5
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:263 → 308
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    3. NM_001199263.3 → NP_001186192.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4

      See identical proteins and their annotated locations for NP_001186192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region and uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) lacks one internal residue and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF151828, AL136370, BC025369, DA255130, DN916480
      Consensus CDS
      CCDS55669.1
      UniProtKB/TrEMBL
      B2RB07
      Related
      ENSP00000356419.1, ENST00000367449.5
      Conserved Domains (1) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    4. NM_001350840.2 → NP_001337769.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BP397519, DR760216
      UniProtKB/TrEMBL
      Q5LJA9
      Conserved Domains (1) summary
      cd02255
      Location:46 → 270
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    5. NM_001350841.2 → NP_001337770.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BP397519, DA255130, DB172473, DR760216
      UniProtKB/TrEMBL
      Q5LJA9
      Related
      ENSP00000356420.3, ENST00000367450.7
      Conserved Domains (2) summary
      cd02255
      Location:8 → 250
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:291 → 336
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    6. NM_001350842.2 → NP_001337771.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BP397519, DA255130, DR760216
      Consensus CDS
      CCDS86041.1
      UniProtKB/TrEMBL
      Q5LJA5, Q5LJA9
      Related
      ENSP00000356421.4, ENST00000367451.8
      Conserved Domains (2) summary
      cd02255
      Location:8 → 250
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:290 → 335
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    7. NM_001350843.2 → NP_001337772.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BC025369, BP397519, DR760216
      UniProtKB/TrEMBL
      Q5LJA9
      Conserved Domains (2) summary
      cd02255
      Location:8 → 250
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:290 → 335
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    8. NM_001350844.2 → NP_001337773.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BP397519
      UniProtKB/TrEMBL
      B2RB07
      Conserved Domains (1) summary
      cd02255
      Location:46 → 243
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    9. NM_001350845.2 → NP_001337774.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF151828, AL136370, BC015521, BC025369, DA255130, DB172473, DN916480, DR760216
      UniProtKB/TrEMBL
      Q5LJA9
      Conserved Domains (1) summary
      cd02255
      Location:8 → 250
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    10. NM_001350846.2 → NP_001337775.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL136370, BM701303, BP397519, CX758593
      UniProtKB/TrEMBL
      B2RB07
      Conserved Domains (1) summary
      cd02255
      Location:12 → 214
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    11. NM_001350847.2 → NP_001337776.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL136370, BP397519, CX758593, DA316048
      UniProtKB/TrEMBL
      B2RB07
      Conserved Domains (1) summary
      cd02255
      Location:12 → 214
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    12. NM_001350848.2 → NP_001337777.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AF147717, AL136370, BP397519, DC295313, DC420886
      UniProtKB/TrEMBL
      B7Z9U9
      Conserved Domains (2) summary
      cd02255
      Location:1 → 99
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:140 → 185
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    13. NM_001350849.2 → NP_001337778.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AF147717, AL136370, BP397519, DA255130, DR422870
      UniProtKB/TrEMBL
      B7Z9U9
      Related
      ENSP00000408720.1, ENST00000420791.5
      Conserved Domains (2) summary
      cd02255
      Location:1 → 99
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:140 → 185
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    14. NM_001350850.2 → NP_001337779.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AF147717, AL136370, BP397519, CB155982, DC295313, DC420886
      UniProtKB/TrEMBL
      B7Z9U9
      Conserved Domains (2) summary
      cd02255
      Location:1 → 99
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:139 → 184
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    15. NM_001350851.2 → NP_001337780.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AF147717, AL136370, BP397519, CB155982, HY081343
      UniProtKB/TrEMBL
      B7Z9U9
      Conserved Domains (2) summary
      cd02255
      Location:1 → 99
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:139 → 184
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    16. NM_001350852.2 → NP_001337781.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AF147717, AL136370, BC025369, BX111590, DC295313, DC420886, DN916480
      UniProtKB/TrEMBL
      B7Z9U9
      Related
      ENSP00000391153.1, ENST00000443327.5
      Conserved Domains (2) summary
      cd02255
      Location:1 → 99
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:139 → 184
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    17. NM_015984.5 → NP_057068.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

      See identical proteins and their annotated locations for NP_057068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AF147717, AL136370, BP397519, DA255130
      Consensus CDS
      CCDS1378.1
      UniProtKB/Swiss-Prot
      Q5LJA6, Q5LJA7, Q8TBS4, Q96BJ9, Q9H1W5, Q9P0I3, Q9UQN2, Q9Y5K5
      UniProtKB/TrEMBL
      B2RB07
      Related
      ENSP00000356425.3, ENST00000367455.8
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264 → 309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    RNA

    1. NR_037607.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon and differs at an internal splice site and at the 3' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK301381, BI548319

    2. NR_146930.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC015521, BC025369, BP397519, BX484791, DR760216

    3. NR_146931.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136370, BC025369, BX484791, DB172473, DN916480, DR760216

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      193012254..193060076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422329.1 → XP_047278285.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X7

      UniProtKB/TrEMBL
      B2RB07

    2. XM_006711370.5 → XP_006711433.3  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X6

      UniProtKB/TrEMBL
      Q5LJA9

    3. XM_017001438.2 → XP_016856927.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

      UniProtKB/TrEMBL
      B7Z9U9
      Conserved Domains (2) summary
      cd02255
      Location:1 → 126
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:167 → 212
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    4. XM_047422333.1 → XP_047278289.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X9

      UniProtKB/TrEMBL
      Q5LJA9

    5. XM_011509607.3 → XP_011507909.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X8

      See identical proteins and their annotated locations for XP_011507909.1

      UniProtKB/TrEMBL
      Q5LJA9
      Conserved Domains (1) summary
      cd02255
      Location:12 → 241
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

    6. XM_006711371.4 → XP_006711434.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

      UniProtKB/TrEMBL
      B7Z9U9
      Conserved Domains (2) summary
      cd02255
      Location:1 → 126
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:167 → 212
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    7. XM_006711367.5 → XP_006711430.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    8. XM_047422360.1 → XP_047278316.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X12

    9. XM_047422366.1 → XP_047278322.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X14

    10. XM_047422371.1 → XP_047278327.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X15

    11. XM_047422353.1 → XP_047278309.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X11

      UniProtKB/TrEMBL
      B2RB07

    12. XM_047422363.1 → XP_047278319.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X13

      UniProtKB/TrEMBL
      B2RB07
      Related
      ENSP00000389563.1, ENST00000421683.1

    13. XM_047422344.1 → XP_047278300.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X10

      UniProtKB/TrEMBL
      Q5LJA9

    14. XM_017001433.3 → XP_016856922.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X3

      UniProtKB/TrEMBL
      B2RB07

    15. XM_006711369.4 → XP_006711432.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

      UniProtKB/TrEMBL
      Q5LJA9

    16. XM_011509604.3 → XP_011507906.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    17. XM_047422372.1 → XP_047278328.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X16

    18. XM_047422310.1 → XP_047278266.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    19. XM_047422324.1 → XP_047278280.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X5

      UniProtKB/TrEMBL
      B2RB07

    20. XM_047422322.1 → XP_047278278.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X4

      UniProtKB/TrEMBL
      B2RB07

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      192359462..192407284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336948.1 → XP_054192923.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X7

      UniProtKB/TrEMBL
      B2RB07

    2. XM_054336947.1 → XP_054192922.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X6

      UniProtKB/TrEMBL
      Q5LJA9

    3. XM_054336958.1 → XP_054192933.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

      UniProtKB/TrEMBL
      B7Z9U9

    4. XM_054336950.1 → XP_054192925.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X9

      UniProtKB/TrEMBL
      Q5LJA9

    5. XM_054336949.1 → XP_054192924.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X8

      UniProtKB/TrEMBL
      Q5LJA9

    6. XM_054336959.1 → XP_054192934.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X17

      UniProtKB/TrEMBL
      B7Z9U9

    7. XM_054336939.1 → XP_054192914.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    8. XM_054336953.1 → XP_054192928.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X12

    9. XM_054336955.1 → XP_054192930.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X14

    10. XM_054336956.1 → XP_054192931.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X15

    11. XM_054336952.1 → XP_054192927.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X11

      UniProtKB/TrEMBL
      B2RB07

    12. XM_054336954.1 → XP_054192929.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X13

      UniProtKB/TrEMBL
      B2RB07

    13. XM_054336951.1 → XP_054192926.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X10

      UniProtKB/TrEMBL
      Q5LJA9

    14. XM_054336944.1 → XP_054192919.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X3

      UniProtKB/TrEMBL
      B2RB07

    15. XM_054336943.1 → XP_054192918.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X19

      UniProtKB/TrEMBL
      B2RB07

    16. XM_054336942.1 → XP_054192917.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

      UniProtKB/TrEMBL
      Q5LJA9

    17. XM_054336941.1 → XP_054192916.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X18

      UniProtKB/TrEMBL
      Q5LJA9

    18. XM_054336938.1 → XP_054192913.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    19. XM_054336957.1 → XP_054192932.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X16

    20. XM_054336940.1 → XP_054192915.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      Q5LJA9

    21. XM_054336946.1 → XP_054192921.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X5

      UniProtKB/TrEMBL
      B2RB07

    22. XM_054336945.1 → XP_054192920.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X4

      UniProtKB/TrEMBL
      B2RB07
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5K5.3 GenPept UniProtKB/Swiss-Prot:Q9Y5K5

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