vtn.L vitronectin L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: vtn.L
Official Full Name: vitronectin L homeolog
Primary source: Xenbase:XB-GENE-989494
Locus tag: XELAEV_18011715mg
See related: EnsemblRapid:ENSXLAG00005032465 AllianceGenome:Xenbase:XB-GENE-989494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: vtn
Summary: Predicted to enable polysaccharide binding activity and scavenger receptor activity. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region. Is expressed in cardiovascular system and liver and biliary system. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 2L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (34831263..34845232)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (33758087..33771937)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016711676.1 (22..296)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vitronectin L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197081.1 → NP_001184010.1 vitronectin L homeolog precursor

See identical proteins and their annotated locations for NP_001184010.1

Status: PROVISIONAL

Source sequence(s)

EU769509

UniProtKB/TrEMBL

A0A974HXH4, C5H606

Related

ENSXLAP00005097302.1, ENSXLAT00005099088.1

Conserved Domains (2) summary

smart00201
Location:22 → 64

SO; Somatomedin B -like domains

cd00094
Location:129 → 433

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...