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    rft-2 Riboflavin transporter;Riboflavin transporter rft-2 [ Caenorhabditis elegans ]

    Gene ID: 178842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rft-2
    Official Full Name
    Riboflavin transporter;Riboflavin transporter rft-2
    Primary source
    WormBase:WBGene00021626
    Locus tag
    CELE_Y47D7A.14
    See related
    AllianceGenome:WB:WBGene00021626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables riboflavin transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; Fazio-Londe disease; and riboflavin deficiency. Orthologous to human SLC52A1 (solute carrier family 52 member 1); SLC52A2 (solute carrier family 52 member 2); and SLC52A3 (solute carrier family 52 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rft-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4443303..4450563, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Riboflavin transporter rft-1 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Riboflavin transporter-2 (rft-2) of Caenorhabditis elegans: Adaptive and developmental regulation. Gandhimathi K, et al. J Biosci, 2015 Jun. PMID 25963255
    2. Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2. Biswas A, et al. PLoS One, 2013. PMID 23483992, Free PMC Article
    3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans riboflavin transporters rft-2 (Y47D7A.14) expression is localized mainly to the intestine and pharynx.
      Title: Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Riboflavin transporter;Riboflavin transporter rft-2
    NP_001256040.1
    • Confirmed by transcript evidence
    NP_001256041.1
    • Partially confirmed by transcript evidence
    NP_001317793.1
    • Confirmed by transcript evidence
    NP_001317853.1
    • Confirmed by transcript evidence
    NP_001317854.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4443303..4450563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269112.3 → NP_001256041.1  Riboflavin transporter rft-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256041.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A168H3J9, G4SDH4, G4SM24, Q95XZ2
      Conserved Domains (1) summary
      pfam06237
      Location:306 → 402
      DUF1011; Protein of unknown function (DUF1011)

    2. NM_001269111.3 → NP_001256040.1  Riboflavin transporter rft-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4SDH4
      Conserved Domains (1) summary
      pfam06237
      Location:294 → 389
      DUF1011; Protein of unknown function (DUF1011)

    3. NM_001330869.3 → NP_001317793.1  Riboflavin transporter rft-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4SDH4

    4. NM_001330870.3 → NP_001317853.1  Riboflavin transporter [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168HBC9

    5. NM_001330871.3 → NP_001317854.1  Riboflavin transporter [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168HBE9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G4SDH4.2

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